CD4(+) Natural Regulatory T Cells Prevent Experimental Cerebral Malaria via CTLA-4 When Expanded In Vivo

Studies in malaria patients indicate that higher frequencies of peripheral blood CD4(+) Foxp3(+) CD25(+) regulatory T (Treg) cells correlate with increased blood parasitemia. This observation implies that Treg cells impair pathogen clearance and thus may be detrimental to the host during infection....

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Detalles Bibliográficos
Autores principales: Haque, Ashraful, Best, Shannon E., Amante, Fiona H., Mustafah, Seri, Desbarrieres, Laure, de Labastida, Fabian, Sparwasser, Tim, Hill, Geoffrey R., Engwerda, Christian R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000360/
https://www.ncbi.nlm.nih.gov/pubmed/21170302
http://dx.doi.org/10.1371/journal.ppat.1001221

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