Cargando…
Evaluation of partial volume effect correction methods for brain positron emission tomography: Quantification and reproducibility
Quantitative accuracy of positron emission tomography (PET) is decreased by the partial volume effect (PVE). The PVE correction (PVC) methods proposed by Alfano et al., Rousset et al., Müller-Gärtner et al. and Meltzer et al. were evaluated in the present study to obtain guidelines for selecting amo...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000501/ https://www.ncbi.nlm.nih.gov/pubmed/21157530 http://dx.doi.org/10.4103/0971-6203.35723 |
_version_ | 1782193548730302464 |
---|---|
author | Harri, Merisaari Mika, Teras Jussi, Hirvonen Nevalainen, Olli S. Jarmo, Hietala |
author_facet | Harri, Merisaari Mika, Teras Jussi, Hirvonen Nevalainen, Olli S. Jarmo, Hietala |
author_sort | Harri, Merisaari |
collection | PubMed |
description | Quantitative accuracy of positron emission tomography (PET) is decreased by the partial volume effect (PVE). The PVE correction (PVC) methods proposed by Alfano et al., Rousset et al., Müller-Gärtner et al. and Meltzer et al. were evaluated in the present study to obtain guidelines for selecting among them. For accuracy evaluation, the Hoffman brain phantom was scanned with three PETs of differing spatial resolution in order to measure the effect of PVC on radioactivity distribution. Test-retest data consisting of duplicate dynamic emission recordings of the dopamine D2-receptor ligand [(11)C] raclopride obtained in eight healthy control subjects were used to test the correction effect in different regions of interest. The PVC method proposed by Alfano et al. gave the best quantification accuracy in the brain gray matter region. When the effect of PVC on reliability was tested with human data, the method of Meltzer et al. proved to be the most reliable. The method by Alfano et al. may be better for group comparison studies and the method by Meltzer et al. for intra-subject drug-effect studies. |
format | Text |
id | pubmed-3000501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-30005012010-12-14 Evaluation of partial volume effect correction methods for brain positron emission tomography: Quantification and reproducibility Harri, Merisaari Mika, Teras Jussi, Hirvonen Nevalainen, Olli S. Jarmo, Hietala J Med Phys Original Article Quantitative accuracy of positron emission tomography (PET) is decreased by the partial volume effect (PVE). The PVE correction (PVC) methods proposed by Alfano et al., Rousset et al., Müller-Gärtner et al. and Meltzer et al. were evaluated in the present study to obtain guidelines for selecting among them. For accuracy evaluation, the Hoffman brain phantom was scanned with three PETs of differing spatial resolution in order to measure the effect of PVC on radioactivity distribution. Test-retest data consisting of duplicate dynamic emission recordings of the dopamine D2-receptor ligand [(11)C] raclopride obtained in eight healthy control subjects were used to test the correction effect in different regions of interest. The PVC method proposed by Alfano et al. gave the best quantification accuracy in the brain gray matter region. When the effect of PVC on reliability was tested with human data, the method of Meltzer et al. proved to be the most reliable. The method by Alfano et al. may be better for group comparison studies and the method by Meltzer et al. for intra-subject drug-effect studies. Medknow Publications 2007 /pmc/articles/PMC3000501/ /pubmed/21157530 http://dx.doi.org/10.4103/0971-6203.35723 Text en © Journal of Medical Physics http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Harri, Merisaari Mika, Teras Jussi, Hirvonen Nevalainen, Olli S. Jarmo, Hietala Evaluation of partial volume effect correction methods for brain positron emission tomography: Quantification and reproducibility |
title | Evaluation of partial volume effect correction methods for brain positron emission tomography: Quantification and reproducibility |
title_full | Evaluation of partial volume effect correction methods for brain positron emission tomography: Quantification and reproducibility |
title_fullStr | Evaluation of partial volume effect correction methods for brain positron emission tomography: Quantification and reproducibility |
title_full_unstemmed | Evaluation of partial volume effect correction methods for brain positron emission tomography: Quantification and reproducibility |
title_short | Evaluation of partial volume effect correction methods for brain positron emission tomography: Quantification and reproducibility |
title_sort | evaluation of partial volume effect correction methods for brain positron emission tomography: quantification and reproducibility |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000501/ https://www.ncbi.nlm.nih.gov/pubmed/21157530 http://dx.doi.org/10.4103/0971-6203.35723 |
work_keys_str_mv | AT harrimerisaari evaluationofpartialvolumeeffectcorrectionmethodsforbrainpositronemissiontomographyquantificationandreproducibility AT mikateras evaluationofpartialvolumeeffectcorrectionmethodsforbrainpositronemissiontomographyquantificationandreproducibility AT jussihirvonen evaluationofpartialvolumeeffectcorrectionmethodsforbrainpositronemissiontomographyquantificationandreproducibility AT nevalainenollis evaluationofpartialvolumeeffectcorrectionmethodsforbrainpositronemissiontomographyquantificationandreproducibility AT jarmohietala evaluationofpartialvolumeeffectcorrectionmethodsforbrainpositronemissiontomographyquantificationandreproducibility |