Functional Characterization of the Promiscuous Prenyltransferase Responsible for Furaquinocin Biosynthesis: IDENTIFICATION OF A PHYSIOLOGICAL POLYKETIDE SUBSTRATE AND ITS PRENYLATED REACTION PRODUCTS

Furaquinocin is a natural polyketide-isoprenoid hybrid (meroterpenoid) that exhibits antitumor activity and is produced by the Streptomyces sp. strain KO-3988. Bioinformatic analysis of furaquinocin biosynthesis has identified Fur7 as a possible prenyltransferase that attaches a geranyl group to an...

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Detalles Bibliográficos
Autores principales: Kumano熊野, Takuto, 匠人, Tomita富田, Takeo, 武郎, Nishiyama西山, Makoto, 真, Kuzuyama葛山, Tomohisa, 智久
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000947/
https://www.ncbi.nlm.nih.gov/pubmed/20937800
http://dx.doi.org/10.1074/jbc.M110.153957

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