Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens

Pregnancy-associatedPlasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here...

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Detalles Bibliográficos
Autores principales: SOERLI, J, BARFOD, L, LAVSTSEN, T, BERNASCONI, N L, LANZAVECCHIA, A, HVIID, L
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001033/
https://www.ncbi.nlm.nih.gov/pubmed/19493213
http://dx.doi.org/10.1111/j.1365-3024.2009.01097.x
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author SOERLI, J
BARFOD, L
LAVSTSEN, T
BERNASCONI, N L
LANZAVECCHIA, A
HVIID, L
author_facet SOERLI, J
BARFOD, L
LAVSTSEN, T
BERNASCONI, N L
LANZAVECCHIA, A
HVIID, L
author_sort SOERLI, J
collection PubMed
description Pregnancy-associatedPlasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSA(PAM)) can be used in vitro to select parasites from nonpregnant donors to express VSA(PAM) and that this selection for VSA(PAM) expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.
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spelling pubmed-30010332010-12-31 Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens SOERLI, J BARFOD, L LAVSTSEN, T BERNASCONI, N L LANZAVECCHIA, A HVIID, L Parasite Immunol Brief Definitive Report Pregnancy-associatedPlasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSA(PAM)) can be used in vitro to select parasites from nonpregnant donors to express VSA(PAM) and that this selection for VSA(PAM) expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA. Blackwell Publishing Ltd 2009-06 /pmc/articles/PMC3001033/ /pubmed/19493213 http://dx.doi.org/10.1111/j.1365-3024.2009.01097.x Text en Journal compilation © 2009 Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Brief Definitive Report
SOERLI, J
BARFOD, L
LAVSTSEN, T
BERNASCONI, N L
LANZAVECCHIA, A
HVIID, L
Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
title Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
title_full Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
title_fullStr Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
title_full_unstemmed Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
title_short Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
title_sort human monoclonal igg selection of plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001033/
https://www.ncbi.nlm.nih.gov/pubmed/19493213
http://dx.doi.org/10.1111/j.1365-3024.2009.01097.x
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