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Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo

Activation-induced cytidine deaminase (AID) protein initiates Ig gene mutation by deaminating cytosines, converting them into uracils. Excision of AID-induced uracils by uracil-N-glycosylase is responsible for most transversion mutations at G:C base pairs. On the other hand, processing of AID-induce...

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Detalles Bibliográficos
Autores principales:	Sharbeen, George, Cook, Adam J. L., Lau, K. K. Edwin, Raftery, Joanna, Yee, Christine W. Y., Jolly, Christopher J.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001060/ https://www.ncbi.nlm.nih.gov/pubmed/20705648 http://dx.doi.org/10.1093/nar/gkq682

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