Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions

Apurinic/apyrimidinic endonuclease 1 (APE1), an essential protein in mammals, is involved in base excision DNA repair (BER) and in regulation of gene expression, acting as a redox co-activator of several transcription factors. Recent findings highlight a novel role for APE1 in RNA metabolism, which...

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Detalles Bibliográficos
Autores principales: Fantini, Damiano, Vascotto, Carlo, Marasco, Daniela, D’Ambrosio, Chiara, Romanello, Milena, Vitagliano, Luigi, Pedone, Carlo, Poletto, Mattia, Cesaratto, Laura, Quadrifoglio, Franco, Scaloni, Andrea, Radicella, J. Pablo, Tell, Gianluca
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001066/
https://www.ncbi.nlm.nih.gov/pubmed/20699270
http://dx.doi.org/10.1093/nar/gkq691

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