The Role of Mitochondria in Brain Aging and the Effects of Melatonin

Melatonin is an endogenous indoleamine present in different tissues, cellular compartments and organelles including mitochondria. When melatonin is administered orally, it is readily available to the brain where it counteracts different processes that occur during aging and age-related neurodegenera...

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Detalles Bibliográficos
Autores principales: Escames, Germaine, López, Ana, García, José Antonio, García, Laura, Acuña-Castroviejo, Darío, García, José Joaquín, López, Luis Carlos
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001212/
https://www.ncbi.nlm.nih.gov/pubmed/21358969
http://dx.doi.org/10.2174/157015910792246245
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author Escames, Germaine
López, Ana
García, José Antonio
García, Laura
Acuña-Castroviejo, Darío
García, José Joaquín
López, Luis Carlos
author_facet Escames, Germaine
López, Ana
García, José Antonio
García, Laura
Acuña-Castroviejo, Darío
García, José Joaquín
López, Luis Carlos
author_sort Escames, Germaine
collection PubMed
description Melatonin is an endogenous indoleamine present in different tissues, cellular compartments and organelles including mitochondria. When melatonin is administered orally, it is readily available to the brain where it counteracts different processes that occur during aging and age-related neurodegenerative disorders. These aging processes include oxidative stress and oxidative damage, chronic and acute inflammation, mitochondrial dysfunction and loss of neural regeneration. This review summarizes age related changes in the brain and the importance of oxidative/nitrosative stress and mitochondrial dysfunction in brain aging. The data and mechanisms of action of melatonin in relation to aging of the brain are reviewed as well.
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spelling pubmed-30012122011-03-01 The Role of Mitochondria in Brain Aging and the Effects of Melatonin Escames, Germaine López, Ana García, José Antonio García, Laura Acuña-Castroviejo, Darío García, José Joaquín López, Luis Carlos Curr Neuropharmacol Article Melatonin is an endogenous indoleamine present in different tissues, cellular compartments and organelles including mitochondria. When melatonin is administered orally, it is readily available to the brain where it counteracts different processes that occur during aging and age-related neurodegenerative disorders. These aging processes include oxidative stress and oxidative damage, chronic and acute inflammation, mitochondrial dysfunction and loss of neural regeneration. This review summarizes age related changes in the brain and the importance of oxidative/nitrosative stress and mitochondrial dysfunction in brain aging. The data and mechanisms of action of melatonin in relation to aging of the brain are reviewed as well. Bentham Science Publishers Ltd. 2010-09 /pmc/articles/PMC3001212/ /pubmed/21358969 http://dx.doi.org/10.2174/157015910792246245 Text en © 2010 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Escames, Germaine
López, Ana
García, José Antonio
García, Laura
Acuña-Castroviejo, Darío
García, José Joaquín
López, Luis Carlos
The Role of Mitochondria in Brain Aging and the Effects of Melatonin
title The Role of Mitochondria in Brain Aging and the Effects of Melatonin
title_full The Role of Mitochondria in Brain Aging and the Effects of Melatonin
title_fullStr The Role of Mitochondria in Brain Aging and the Effects of Melatonin
title_full_unstemmed The Role of Mitochondria in Brain Aging and the Effects of Melatonin
title_short The Role of Mitochondria in Brain Aging and the Effects of Melatonin
title_sort role of mitochondria in brain aging and the effects of melatonin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001212/
https://www.ncbi.nlm.nih.gov/pubmed/21358969
http://dx.doi.org/10.2174/157015910792246245
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