Cargando…
Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease
Alzheimer disease (AD) is an age-related neurodegenerative disorder characterized by the presence of senile plaques, neurofibrillary tangles and neuronal loss. Amyloid-β protein (Aβ) deposition plays a critical role in the development of AD. It is now generally accepted that massive neuronal death d...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers Ltd
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001214/ https://www.ncbi.nlm.nih.gov/pubmed/21358971 http://dx.doi.org/10.2174/157015910792246137 |
_version_ | 1782193614680489984 |
---|---|
author | He, Hongwen Dong, Weiguo Huang, Fang |
author_facet | He, Hongwen Dong, Weiguo Huang, Fang |
author_sort | He, Hongwen |
collection | PubMed |
description | Alzheimer disease (AD) is an age-related neurodegenerative disorder characterized by the presence of senile plaques, neurofibrillary tangles and neuronal loss. Amyloid-β protein (Aβ) deposition plays a critical role in the development of AD. It is now generally accepted that massive neuronal death due to apoptosis is a common characteristic in the brains of patients suffering from neurodegenerative diseases, and apoptotic cell death has been found in neurons and glial cells in AD. Melatonin is a secretory product of the pineal gland; melatonin is a potent antioxidant and free radical scavenger and may play an important role in aging and AD. Melatonin decreases during aging and patients with AD have a more profound reduction of this indoleamine. Additionally, the antioxidant properties, the anti-amyloidogenic properties and anti-apoptotic properties of melatonin in AD models have been studied. In this article, we review the anti-amyloidogenic and anti-apoptotic role of melatonin in AD |
format | Text |
id | pubmed-3001214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Bentham Science Publishers Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-30012142011-03-01 Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease He, Hongwen Dong, Weiguo Huang, Fang Curr Neuropharmacol Article Alzheimer disease (AD) is an age-related neurodegenerative disorder characterized by the presence of senile plaques, neurofibrillary tangles and neuronal loss. Amyloid-β protein (Aβ) deposition plays a critical role in the development of AD. It is now generally accepted that massive neuronal death due to apoptosis is a common characteristic in the brains of patients suffering from neurodegenerative diseases, and apoptotic cell death has been found in neurons and glial cells in AD. Melatonin is a secretory product of the pineal gland; melatonin is a potent antioxidant and free radical scavenger and may play an important role in aging and AD. Melatonin decreases during aging and patients with AD have a more profound reduction of this indoleamine. Additionally, the antioxidant properties, the anti-amyloidogenic properties and anti-apoptotic properties of melatonin in AD models have been studied. In this article, we review the anti-amyloidogenic and anti-apoptotic role of melatonin in AD Bentham Science Publishers Ltd 2010-09 /pmc/articles/PMC3001214/ /pubmed/21358971 http://dx.doi.org/10.2174/157015910792246137 Text en ©2010 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article He, Hongwen Dong, Weiguo Huang, Fang Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease |
title | Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease |
title_full | Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease |
title_fullStr | Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease |
title_full_unstemmed | Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease |
title_short | Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease |
title_sort | anti-amyloidogenic and anti-apoptotic role of melatonin in alzheimer disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001214/ https://www.ncbi.nlm.nih.gov/pubmed/21358971 http://dx.doi.org/10.2174/157015910792246137 |
work_keys_str_mv | AT hehongwen antiamyloidogenicandantiapoptoticroleofmelatonininalzheimerdisease AT dongweiguo antiamyloidogenicandantiapoptoticroleofmelatonininalzheimerdisease AT huangfang antiamyloidogenicandantiapoptoticroleofmelatonininalzheimerdisease |