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How the vertebrates were made: selective pruning of a double-duplicated genome

Vertebrates are the result of an ancient double duplication of the genome. A new study published in BMC Biology explores the selective retention of genes after this event, finding an extensive enrichment of signaling proteins and transcription factors. Analysis of their expression patterns, interact...

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Detalles Bibliográficos
Autores principales: Manning, Gerard, Scheeff, Eric
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001425/
https://www.ncbi.nlm.nih.gov/pubmed/21144066
http://dx.doi.org/10.1186/1741-7007-8-144
Descripción
Sumario:Vertebrates are the result of an ancient double duplication of the genome. A new study published in BMC Biology explores the selective retention of genes after this event, finding an extensive enrichment of signaling proteins and transcription factors. Analysis of their expression patterns, interactions and subsequent history reflect the forces that drove their evolution, and with it the evolution of vertebrate complexity. See research article: http://www.biomedcentral.com/1741-7007/8/146/abstract