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COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma

BACKGROUND: KRAS mutational analysis is the standard of care prior to initiation of treatments targeting the epidermal growth factor receptor (EGFR) in patients with metastatic colorectal cancer. Sensitive methods are required to reliably detect KRAS mutations in tumor samples due to admixture with...

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Detalles Bibliográficos
Autores principales:	Pritchard, Colin C, Akagi, Laura, Reddy, Poluru L, Joseph, Loren, Tait, Jonathan F
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Technical Advance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001699/ https://www.ncbi.nlm.nih.gov/pubmed/21110880 http://dx.doi.org/10.1186/1472-6890-10-6

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