Current concepts regarding the HTLV-1 receptor complex

The identity of the Human T lymphotropic Virus type 1 (HTLV-1) receptor remained an unsolved puzzle for two decades, until the recent demonstration that three molecules, Glucose Transporter 1, Neuropilin-1 and Heparan Sulfate Proteoglycans are involved in HTLV-1 binding and entry. Despite these adva...

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Detalles Bibliográficos
Autores principales: Ghez, David, Lepelletier, Yves, Jones, Kathryn S, Pique, Claudine, Hermine, Olivier
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001707/
https://www.ncbi.nlm.nih.gov/pubmed/21114861
http://dx.doi.org/10.1186/1742-4690-7-99
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author Ghez, David
Lepelletier, Yves
Jones, Kathryn S
Pique, Claudine
Hermine, Olivier
author_facet Ghez, David
Lepelletier, Yves
Jones, Kathryn S
Pique, Claudine
Hermine, Olivier
author_sort Ghez, David
collection PubMed
description The identity of the Human T lymphotropic Virus type 1 (HTLV-1) receptor remained an unsolved puzzle for two decades, until the recent demonstration that three molecules, Glucose Transporter 1, Neuropilin-1 and Heparan Sulfate Proteoglycans are involved in HTLV-1 binding and entry. Despite these advances, several questions remain unanswered, including the precise role of each of these molecules during virus entry. In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection.
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spelling pubmed-30017072010-12-15 Current concepts regarding the HTLV-1 receptor complex Ghez, David Lepelletier, Yves Jones, Kathryn S Pique, Claudine Hermine, Olivier Retrovirology Review The identity of the Human T lymphotropic Virus type 1 (HTLV-1) receptor remained an unsolved puzzle for two decades, until the recent demonstration that three molecules, Glucose Transporter 1, Neuropilin-1 and Heparan Sulfate Proteoglycans are involved in HTLV-1 binding and entry. Despite these advances, several questions remain unanswered, including the precise role of each of these molecules during virus entry. In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection. BioMed Central 2010-11-29 /pmc/articles/PMC3001707/ /pubmed/21114861 http://dx.doi.org/10.1186/1742-4690-7-99 Text en Copyright ©2010 Ghez et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Ghez, David
Lepelletier, Yves
Jones, Kathryn S
Pique, Claudine
Hermine, Olivier
Current concepts regarding the HTLV-1 receptor complex
title Current concepts regarding the HTLV-1 receptor complex
title_full Current concepts regarding the HTLV-1 receptor complex
title_fullStr Current concepts regarding the HTLV-1 receptor complex
title_full_unstemmed Current concepts regarding the HTLV-1 receptor complex
title_short Current concepts regarding the HTLV-1 receptor complex
title_sort current concepts regarding the htlv-1 receptor complex
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001707/
https://www.ncbi.nlm.nih.gov/pubmed/21114861
http://dx.doi.org/10.1186/1742-4690-7-99
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