Systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report

BACKGROUND: We report on the case of an established perinuclear antineutrophil cytoplasmic antibody (pANCA) associated renal vasculitis being treated with prednisolone and rituximab, where the patient presented with leg weakness, urinary and faecal incontinence and buttock pain consistent with trans...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamilton, Alexander J, Whitehead, Duncan J, Bull, Matthew D, D'Souza, Richard J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001708/
https://www.ncbi.nlm.nih.gov/pubmed/21118568
http://dx.doi.org/10.1186/1471-2377-10-118
_version_ 1782193650350948352
author Hamilton, Alexander J
Whitehead, Duncan J
Bull, Matthew D
D'Souza, Richard J
author_facet Hamilton, Alexander J
Whitehead, Duncan J
Bull, Matthew D
D'Souza, Richard J
author_sort Hamilton, Alexander J
collection PubMed
description BACKGROUND: We report on the case of an established perinuclear antineutrophil cytoplasmic antibody (pANCA) associated renal vasculitis being treated with prednisolone and rituximab, where the patient presented with leg weakness, urinary and faecal incontinence and buttock pain consistent with transverse myelitis. CASE PRESENTATION: The patient underwent MRI scanning showing patchy cord enhancement from T10 to the conus, which was suggestive of a cord malignancy. Prior to a cord biopsy, he was treated with steroids and a repeat MRI showed resolution of the original lesion with a new similar lesion from C7 to T3. CONCLUSIONS: He made a marked recovery after further treatment with high dose steroids and plasma exchange.
format Text
id pubmed-3001708
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-30017082010-12-15 Systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report Hamilton, Alexander J Whitehead, Duncan J Bull, Matthew D D'Souza, Richard J BMC Neurol Case Report BACKGROUND: We report on the case of an established perinuclear antineutrophil cytoplasmic antibody (pANCA) associated renal vasculitis being treated with prednisolone and rituximab, where the patient presented with leg weakness, urinary and faecal incontinence and buttock pain consistent with transverse myelitis. CASE PRESENTATION: The patient underwent MRI scanning showing patchy cord enhancement from T10 to the conus, which was suggestive of a cord malignancy. Prior to a cord biopsy, he was treated with steroids and a repeat MRI showed resolution of the original lesion with a new similar lesion from C7 to T3. CONCLUSIONS: He made a marked recovery after further treatment with high dose steroids and plasma exchange. BioMed Central 2010-11-30 /pmc/articles/PMC3001708/ /pubmed/21118568 http://dx.doi.org/10.1186/1471-2377-10-118 Text en Copyright ©2010 Hamilton et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hamilton, Alexander J
Whitehead, Duncan J
Bull, Matthew D
D'Souza, Richard J
Systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report
title Systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report
title_full Systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report
title_fullStr Systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report
title_full_unstemmed Systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report
title_short Systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report
title_sort systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001708/
https://www.ncbi.nlm.nih.gov/pubmed/21118568
http://dx.doi.org/10.1186/1471-2377-10-118
work_keys_str_mv AT hamiltonalexanderj systemicpancaassociatedvasculitiswithcentralnervousinvolvementcausingrecurrentmyelitiscasereport
AT whiteheadduncanj systemicpancaassociatedvasculitiswithcentralnervousinvolvementcausingrecurrentmyelitiscasereport
AT bullmatthewd systemicpancaassociatedvasculitiswithcentralnervousinvolvementcausingrecurrentmyelitiscasereport
AT dsouzarichardj systemicpancaassociatedvasculitiswithcentralnervousinvolvementcausingrecurrentmyelitiscasereport

Ejemplares similares