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Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation

Epigenetic modifications play a key role in the patho-physiology of many tumors and the current use of agents targeting epigenetic changes has become a topic of intense interest in cancer research. DNA methyltransferase (DNMT) inhibitors represent a promising class of epigenetic modulators. Research...

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Detalles Bibliográficos
Autores principales:	Gravina, Giovanni L, Festuccia, Claudio, Marampon, Francesco, Popov, Vladimir M, Pestell, Richard G, Zani, Bianca M, Tombolini, Vincenzo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001713/ https://www.ncbi.nlm.nih.gov/pubmed/21108789 http://dx.doi.org/10.1186/1476-4598-9-305

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