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Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase

BACKGROUND: Activation of the RON receptor tyrosine kinase, a member of the c-MET family, regulates tumorigenic phenotypes. The RON extracellular domains are critical in regulating these activities. The objective of this study was to determine the role of the first IPT domain in regulating RON-media...

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Detalles Bibliográficos
Autores principales: Ma, Qi, Zhang, Kun, Guin, Sunny, Zhou, Yong-Qing, Wang, Ming-Hai
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001714/
https://www.ncbi.nlm.nih.gov/pubmed/21114864
http://dx.doi.org/10.1186/1476-4598-9-307