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The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis
BACKGROUND: Efforts to prevent the development of overweight and obesity have increasingly focused early in the life course as we recognise that both metabolic and behavioural patterns are often established within the first few years of life. Randomised controlled trials (RCTs) of interventions are...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001735/ https://www.ncbi.nlm.nih.gov/pubmed/21106110 http://dx.doi.org/10.1186/1471-2458-10-728 |
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author | Askie, Lisa M Baur, Louise A Campbell, Karen Daniels, Lynne A Hesketh, Kylie Magarey, Anthea Mihrshahi, Seema Rissel, Chris Simes, John Taylor, Barry Taylor, Rachael Voysey, Merryn Wen, Li Ming |
author_facet | Askie, Lisa M Baur, Louise A Campbell, Karen Daniels, Lynne A Hesketh, Kylie Magarey, Anthea Mihrshahi, Seema Rissel, Chris Simes, John Taylor, Barry Taylor, Rachael Voysey, Merryn Wen, Li Ming |
author_sort | Askie, Lisa M |
collection | PubMed |
description | BACKGROUND: Efforts to prevent the development of overweight and obesity have increasingly focused early in the life course as we recognise that both metabolic and behavioural patterns are often established within the first few years of life. Randomised controlled trials (RCTs) of interventions are even more powerful when, with forethought, they are synthesised into an individual patient data (IPD) prospective meta-analysis (PMA). An IPD PMA is a unique research design where several trials are identified for inclusion in an analysis before any of the individual trial results become known and the data are provided for each randomised patient. This methodology minimises the publication and selection bias often associated with a retrospective meta-analysis by allowing hypotheses, analysis methods and selection criteria to be specified a priori. METHODS/DESIGN: The Early Prevention of Obesity in CHildren (EPOCH) Collaboration was formed in 2009. The main objective of the EPOCH Collaboration is to determine if early intervention for childhood obesity impacts on body mass index (BMI) z scores at age 18-24 months. Additional research questions will focus on whether early intervention has an impact on children's dietary quality, TV viewing time, duration of breastfeeding and parenting styles. This protocol includes the hypotheses, inclusion criteria and outcome measures to be used in the IPD PMA. The sample size of the combined dataset at final outcome assessment (approximately 1800 infants) will allow greater precision when exploring differences in the effect of early intervention with respect to pre-specified participant- and intervention-level characteristics. DISCUSSION: Finalisation of the data collection procedures and analysis plans will be complete by the end of 2010. Data collection and analysis will occur during 2011-2012 and results should be available by 2013. TRIAL REGISTRATION NUMBER: ACTRN12610000789066 |
format | Text |
id | pubmed-3001735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30017352010-12-15 The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis Askie, Lisa M Baur, Louise A Campbell, Karen Daniels, Lynne A Hesketh, Kylie Magarey, Anthea Mihrshahi, Seema Rissel, Chris Simes, John Taylor, Barry Taylor, Rachael Voysey, Merryn Wen, Li Ming BMC Public Health Study Protocol BACKGROUND: Efforts to prevent the development of overweight and obesity have increasingly focused early in the life course as we recognise that both metabolic and behavioural patterns are often established within the first few years of life. Randomised controlled trials (RCTs) of interventions are even more powerful when, with forethought, they are synthesised into an individual patient data (IPD) prospective meta-analysis (PMA). An IPD PMA is a unique research design where several trials are identified for inclusion in an analysis before any of the individual trial results become known and the data are provided for each randomised patient. This methodology minimises the publication and selection bias often associated with a retrospective meta-analysis by allowing hypotheses, analysis methods and selection criteria to be specified a priori. METHODS/DESIGN: The Early Prevention of Obesity in CHildren (EPOCH) Collaboration was formed in 2009. The main objective of the EPOCH Collaboration is to determine if early intervention for childhood obesity impacts on body mass index (BMI) z scores at age 18-24 months. Additional research questions will focus on whether early intervention has an impact on children's dietary quality, TV viewing time, duration of breastfeeding and parenting styles. This protocol includes the hypotheses, inclusion criteria and outcome measures to be used in the IPD PMA. The sample size of the combined dataset at final outcome assessment (approximately 1800 infants) will allow greater precision when exploring differences in the effect of early intervention with respect to pre-specified participant- and intervention-level characteristics. DISCUSSION: Finalisation of the data collection procedures and analysis plans will be complete by the end of 2010. Data collection and analysis will occur during 2011-2012 and results should be available by 2013. TRIAL REGISTRATION NUMBER: ACTRN12610000789066 BioMed Central 2010-11-25 /pmc/articles/PMC3001735/ /pubmed/21106110 http://dx.doi.org/10.1186/1471-2458-10-728 Text en Copyright ©2010 Askie et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Study Protocol Askie, Lisa M Baur, Louise A Campbell, Karen Daniels, Lynne A Hesketh, Kylie Magarey, Anthea Mihrshahi, Seema Rissel, Chris Simes, John Taylor, Barry Taylor, Rachael Voysey, Merryn Wen, Li Ming The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis |
title | The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis |
title_full | The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis |
title_fullStr | The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis |
title_full_unstemmed | The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis |
title_short | The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis |
title_sort | early prevention of obesity in children (epoch) collaboration - an individual patient data prospective meta-analysis |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001735/ https://www.ncbi.nlm.nih.gov/pubmed/21106110 http://dx.doi.org/10.1186/1471-2458-10-728 |
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