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Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations
BACKGROUND: In a recent study, two-dimensional (2D) network layouts were used to visualize and quantitatively analyze the relationship between chronic renal diseases and regulated genes. The results revealed complex relationships between disease type, gene specificity, and gene regulation type, whic...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001742/ https://www.ncbi.nlm.nih.gov/pubmed/21070623 http://dx.doi.org/10.1186/1756-0500-3-296 |
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author | Bhavnani, Suresh K Ganesan, Arunkumaar Hall, Theodore Maslowski, Eric Eichinger, Felix Martini, Sebastian Saxman, Paul Bellala, Gowtham Kretzler, Matthias |
author_facet | Bhavnani, Suresh K Ganesan, Arunkumaar Hall, Theodore Maslowski, Eric Eichinger, Felix Martini, Sebastian Saxman, Paul Bellala, Gowtham Kretzler, Matthias |
author_sort | Bhavnani, Suresh K |
collection | PubMed |
description | BACKGROUND: In a recent study, two-dimensional (2D) network layouts were used to visualize and quantitatively analyze the relationship between chronic renal diseases and regulated genes. The results revealed complex relationships between disease type, gene specificity, and gene regulation type, which led to important insights about the underlying biological pathways. Here we describe an attempt to extend our understanding of these complex relationships by reanalyzing the data using three-dimensional (3D) network layouts, displayed through 2D and 3D viewing methods. FINDINGS: The 3D network layout (displayed through the 3D viewing method) revealed that genes implicated in many diseases (non-specific genes) tended to be predominantly down-regulated, whereas genes regulated in a few diseases (disease-specific genes) tended to be up-regulated. This new global relationship was quantitatively validated through comparison to 1000 random permutations of networks of the same size and distribution. Our new finding appeared to be the result of using specific features of the 3D viewing method to analyze the 3D renal network. CONCLUSIONS: The global relationship between gene regulation and gene specificity is the first clue from human studies that there exist common mechanisms across several renal diseases, which suggest hypotheses for the underlying mechanisms. Furthermore, the study suggests hypotheses for why the 3D visualization helped to make salient a new regularity that was difficult to detect in 2D. Future research that tests these hypotheses should enable a more systematic understanding of when and how to use 3D network visualizations to reveal complex regularities in biological networks. |
format | Text |
id | pubmed-3001742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30017422010-12-15 Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations Bhavnani, Suresh K Ganesan, Arunkumaar Hall, Theodore Maslowski, Eric Eichinger, Felix Martini, Sebastian Saxman, Paul Bellala, Gowtham Kretzler, Matthias BMC Res Notes Short Report BACKGROUND: In a recent study, two-dimensional (2D) network layouts were used to visualize and quantitatively analyze the relationship between chronic renal diseases and regulated genes. The results revealed complex relationships between disease type, gene specificity, and gene regulation type, which led to important insights about the underlying biological pathways. Here we describe an attempt to extend our understanding of these complex relationships by reanalyzing the data using three-dimensional (3D) network layouts, displayed through 2D and 3D viewing methods. FINDINGS: The 3D network layout (displayed through the 3D viewing method) revealed that genes implicated in many diseases (non-specific genes) tended to be predominantly down-regulated, whereas genes regulated in a few diseases (disease-specific genes) tended to be up-regulated. This new global relationship was quantitatively validated through comparison to 1000 random permutations of networks of the same size and distribution. Our new finding appeared to be the result of using specific features of the 3D viewing method to analyze the 3D renal network. CONCLUSIONS: The global relationship between gene regulation and gene specificity is the first clue from human studies that there exist common mechanisms across several renal diseases, which suggest hypotheses for the underlying mechanisms. Furthermore, the study suggests hypotheses for why the 3D visualization helped to make salient a new regularity that was difficult to detect in 2D. Future research that tests these hypotheses should enable a more systematic understanding of when and how to use 3D network visualizations to reveal complex regularities in biological networks. BioMed Central 2010-11-11 /pmc/articles/PMC3001742/ /pubmed/21070623 http://dx.doi.org/10.1186/1756-0500-3-296 Text en Copyright ©2010 Bhavnani et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Bhavnani, Suresh K Ganesan, Arunkumaar Hall, Theodore Maslowski, Eric Eichinger, Felix Martini, Sebastian Saxman, Paul Bellala, Gowtham Kretzler, Matthias Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations |
title | Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations |
title_full | Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations |
title_fullStr | Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations |
title_full_unstemmed | Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations |
title_short | Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations |
title_sort | discovering hidden relationships between renal diseases and regulated genes through 3d network visualizations |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001742/ https://www.ncbi.nlm.nih.gov/pubmed/21070623 http://dx.doi.org/10.1186/1756-0500-3-296 |
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