Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

BACKGROUND: Lamins A and C, encoded by the LMNA gene, are filamentous proteins that form the core scaffold of the nuclear lamina. Dominant LMNA gene mutations cause multiple human diseases including cardiac and skeletal myopathies. The nuclear lamina is thought to regulate gene expression by its dir...

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Detalles Bibliográficos
Autores principales: Mewborn, Stephanie K., Puckelwartz, Megan J., Abuisneineh, Fida, Fahrenbach, John P., Zhang, Yuan, MacLeod, Heather, Dellefave, Lisa, Pytel, Peter, Selig, Sara, Labno, Christine M., Reddy, Karen, Singh, Harinder, McNally, Elizabeth
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001866/
https://www.ncbi.nlm.nih.gov/pubmed/21179469
http://dx.doi.org/10.1371/journal.pone.0014342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001866/
https://www.ncbi.nlm.nih.gov/pubmed/21179469
http://dx.doi.org/10.1371/journal.pone.0014342

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