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Human Antibody Responses to the Anopheles Salivary gSG6-P1 Peptide: A Novel Tool for Evaluating the Efficacy of ITNs in Malaria Vector Control

To optimize malaria control, WHO has prioritised the need for new indicators to evaluate the efficacy of malaria vector control strategies. The gSG6-P1 peptide from gSG6 protein of Anopheles gambiae salivary glands was previously designed as a specific salivary sequence of malaria vector species. It...

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Autores principales: Drame, Papa Makhtar, Poinsignon, Anne, Besnard, Patrick, Cornelie, Sylvie, Le Mire, Jacques, Toto, Jean-Claude, Foumane, Vincent, Dos-Santos, Maria Adelaide, Sembène, Mbacké, Fortes, Filomeno, Simondon, Francois, Carnevale, Pierre, Remoue, Franck
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001874/
https://www.ncbi.nlm.nih.gov/pubmed/21179476
http://dx.doi.org/10.1371/journal.pone.0015596
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author Drame, Papa Makhtar
Poinsignon, Anne
Besnard, Patrick
Cornelie, Sylvie
Le Mire, Jacques
Toto, Jean-Claude
Foumane, Vincent
Dos-Santos, Maria Adelaide
Sembène, Mbacké
Fortes, Filomeno
Simondon, Francois
Carnevale, Pierre
Remoue, Franck
author_facet Drame, Papa Makhtar
Poinsignon, Anne
Besnard, Patrick
Cornelie, Sylvie
Le Mire, Jacques
Toto, Jean-Claude
Foumane, Vincent
Dos-Santos, Maria Adelaide
Sembène, Mbacké
Fortes, Filomeno
Simondon, Francois
Carnevale, Pierre
Remoue, Franck
author_sort Drame, Papa Makhtar
collection PubMed
description To optimize malaria control, WHO has prioritised the need for new indicators to evaluate the efficacy of malaria vector control strategies. The gSG6-P1 peptide from gSG6 protein of Anopheles gambiae salivary glands was previously designed as a specific salivary sequence of malaria vector species. It was shown that the quantification of human antibody (Ab) responses to Anopheles salivary proteins in general and especially to the gSG6-P1 peptide was a pertinent biomarker of human exposure to Anopheles. The present objective was to validate this indicator in the evaluation of the efficacy of Insecticide Treated Nets (ITNs). A longitudinal evaluation, including parasitological, entomological and immunological assessments, was conducted on children and adults from a malaria-endemic area before and after the introduction of ITNs. Significant decrease of anti-gSG6-P1 IgG response was observed just after the efficient ITNs use. Interestingly, specific IgG Ab level was especially pertinent to evaluate a short-time period of ITNs efficacy and at individual level. However, specific IgG rose back up within four months as correct ITN use waned. IgG responses to one salivary peptide could constitute a reliable biomarker for the evaluation of ITN efficacy, at short- and long-term use, and provide a valuable tool in malaria vector control based on a real measurement of human-vector contact.
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spelling pubmed-30018742010-12-21 Human Antibody Responses to the Anopheles Salivary gSG6-P1 Peptide: A Novel Tool for Evaluating the Efficacy of ITNs in Malaria Vector Control Drame, Papa Makhtar Poinsignon, Anne Besnard, Patrick Cornelie, Sylvie Le Mire, Jacques Toto, Jean-Claude Foumane, Vincent Dos-Santos, Maria Adelaide Sembène, Mbacké Fortes, Filomeno Simondon, Francois Carnevale, Pierre Remoue, Franck PLoS One Research Article To optimize malaria control, WHO has prioritised the need for new indicators to evaluate the efficacy of malaria vector control strategies. The gSG6-P1 peptide from gSG6 protein of Anopheles gambiae salivary glands was previously designed as a specific salivary sequence of malaria vector species. It was shown that the quantification of human antibody (Ab) responses to Anopheles salivary proteins in general and especially to the gSG6-P1 peptide was a pertinent biomarker of human exposure to Anopheles. The present objective was to validate this indicator in the evaluation of the efficacy of Insecticide Treated Nets (ITNs). A longitudinal evaluation, including parasitological, entomological and immunological assessments, was conducted on children and adults from a malaria-endemic area before and after the introduction of ITNs. Significant decrease of anti-gSG6-P1 IgG response was observed just after the efficient ITNs use. Interestingly, specific IgG Ab level was especially pertinent to evaluate a short-time period of ITNs efficacy and at individual level. However, specific IgG rose back up within four months as correct ITN use waned. IgG responses to one salivary peptide could constitute a reliable biomarker for the evaluation of ITN efficacy, at short- and long-term use, and provide a valuable tool in malaria vector control based on a real measurement of human-vector contact. Public Library of Science 2010-12-14 /pmc/articles/PMC3001874/ /pubmed/21179476 http://dx.doi.org/10.1371/journal.pone.0015596 Text en Drame et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Drame, Papa Makhtar
Poinsignon, Anne
Besnard, Patrick
Cornelie, Sylvie
Le Mire, Jacques
Toto, Jean-Claude
Foumane, Vincent
Dos-Santos, Maria Adelaide
Sembène, Mbacké
Fortes, Filomeno
Simondon, Francois
Carnevale, Pierre
Remoue, Franck
Human Antibody Responses to the Anopheles Salivary gSG6-P1 Peptide: A Novel Tool for Evaluating the Efficacy of ITNs in Malaria Vector Control
title Human Antibody Responses to the Anopheles Salivary gSG6-P1 Peptide: A Novel Tool for Evaluating the Efficacy of ITNs in Malaria Vector Control
title_full Human Antibody Responses to the Anopheles Salivary gSG6-P1 Peptide: A Novel Tool for Evaluating the Efficacy of ITNs in Malaria Vector Control
title_fullStr Human Antibody Responses to the Anopheles Salivary gSG6-P1 Peptide: A Novel Tool for Evaluating the Efficacy of ITNs in Malaria Vector Control
title_full_unstemmed Human Antibody Responses to the Anopheles Salivary gSG6-P1 Peptide: A Novel Tool for Evaluating the Efficacy of ITNs in Malaria Vector Control
title_short Human Antibody Responses to the Anopheles Salivary gSG6-P1 Peptide: A Novel Tool for Evaluating the Efficacy of ITNs in Malaria Vector Control
title_sort human antibody responses to the anopheles salivary gsg6-p1 peptide: a novel tool for evaluating the efficacy of itns in malaria vector control
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001874/
https://www.ncbi.nlm.nih.gov/pubmed/21179476
http://dx.doi.org/10.1371/journal.pone.0015596
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