High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

The circadian clock underlies daily rhythms of diverse physiological processes, and alterations in clock function have been linked to numerous pathologies. To apply chemical biology methods to modulate and dissect the clock mechanism with new chemical probes, we performed a circadian screen of ∼120,...

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Detalles Bibliográficos
Autores principales: Hirota, Tsuyoshi, Lee, Jae Wook, Lewis, Warren G., Zhang, Eric E., Breton, Ghislain, Liu, Xianzhong, Garcia, Michael, Peters, Eric C., Etchegaray, Jean-Pierre, Traver, David, Schultz, Peter G., Kay, Steve A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001897/
https://www.ncbi.nlm.nih.gov/pubmed/21179498
http://dx.doi.org/10.1371/journal.pbio.1000559

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