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Is vaccine the magic bullet for malaria elimination? A reality check

Malaria remains a major health burden especially for the developing countries. Despite concerted efforts at using the current control tools, such as bed nets, anti malarial drugs and vector control measures, the disease is accountable for close to a million deaths annually. Vaccines have been propos...

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Detalles Bibliográficos
Autores principales: Chilengi, Roma, Gitaka, Jesse
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002145/
https://www.ncbi.nlm.nih.gov/pubmed/20423536
http://dx.doi.org/10.1186/1475-2875-9-S3-S1
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author Chilengi, Roma
Gitaka, Jesse
author_facet Chilengi, Roma
Gitaka, Jesse
author_sort Chilengi, Roma
collection PubMed
description Malaria remains a major health burden especially for the developing countries. Despite concerted efforts at using the current control tools, such as bed nets, anti malarial drugs and vector control measures, the disease is accountable for close to a million deaths annually. Vaccines have been proposed as a necessary addition to the armamentarium that could work towards elimination and eventual eradication of malaria in view of their historical significance in combating infectious diseases. However, because malaria vaccines would work differently depending on the targeted parasite stage, this review addresses the potential impact various malaria vaccine types could have on transmission. Further, because of the wide variation in the epidemiology of malaria across the endemic regions, this paper proposes that the ideal approach to malaria control ought to be tailor-made depending on the specific context. Finally, it suggests that although it is highly desirable to anticipate and aim for malaria elimination and eventual eradication, many affected regions should prioritize reduction of mortality and morbidity before aspiring for elimination.
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spelling pubmed-30021452010-12-16 Is vaccine the magic bullet for malaria elimination? A reality check Chilengi, Roma Gitaka, Jesse Malar J Review Malaria remains a major health burden especially for the developing countries. Despite concerted efforts at using the current control tools, such as bed nets, anti malarial drugs and vector control measures, the disease is accountable for close to a million deaths annually. Vaccines have been proposed as a necessary addition to the armamentarium that could work towards elimination and eventual eradication of malaria in view of their historical significance in combating infectious diseases. However, because malaria vaccines would work differently depending on the targeted parasite stage, this review addresses the potential impact various malaria vaccine types could have on transmission. Further, because of the wide variation in the epidemiology of malaria across the endemic regions, this paper proposes that the ideal approach to malaria control ought to be tailor-made depending on the specific context. Finally, it suggests that although it is highly desirable to anticipate and aim for malaria elimination and eventual eradication, many affected regions should prioritize reduction of mortality and morbidity before aspiring for elimination. BioMed Central 2010-12-13 /pmc/articles/PMC3002145/ /pubmed/20423536 http://dx.doi.org/10.1186/1475-2875-9-S3-S1 Text en Copyright ©2010 Chilengi and Gitaka; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Chilengi, Roma
Gitaka, Jesse
Is vaccine the magic bullet for malaria elimination? A reality check
title Is vaccine the magic bullet for malaria elimination? A reality check
title_full Is vaccine the magic bullet for malaria elimination? A reality check
title_fullStr Is vaccine the magic bullet for malaria elimination? A reality check
title_full_unstemmed Is vaccine the magic bullet for malaria elimination? A reality check
title_short Is vaccine the magic bullet for malaria elimination? A reality check
title_sort is vaccine the magic bullet for malaria elimination? a reality check
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002145/
https://www.ncbi.nlm.nih.gov/pubmed/20423536
http://dx.doi.org/10.1186/1475-2875-9-S3-S1
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