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Primate and Rodent Specific Intron Gains and the Origin of Retrogenes with Splice Variants

Retroposition, a leading mechanism for gene duplication, is an important process shaping the evolution of genomes. Retrogenes are also involved in the gene structure evolution as a major player in the process of intron deletion. Here, we demonstrate the role of retrogenes in intron gain in mammals....

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Autores principales: Szcześniak, Michał W, Ciomborowska, Joanna, Nowak, Witold, Rogozin, Igor B, Makałowska, Izabela
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002245/
https://www.ncbi.nlm.nih.gov/pubmed/20889727
http://dx.doi.org/10.1093/molbev/msq260
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author Szcześniak, Michał W
Ciomborowska, Joanna
Nowak, Witold
Rogozin, Igor B
Makałowska, Izabela
author_facet Szcześniak, Michał W
Ciomborowska, Joanna
Nowak, Witold
Rogozin, Igor B
Makałowska, Izabela
author_sort Szcześniak, Michał W
collection PubMed
description Retroposition, a leading mechanism for gene duplication, is an important process shaping the evolution of genomes. Retrogenes are also involved in the gene structure evolution as a major player in the process of intron deletion. Here, we demonstrate the role of retrogenes in intron gain in mammals. We identified one case of “intronization,” the transformation of exonic sequences into an intron, in the primate specific retrogene RNF113B and two independent “intronization” events in the retrogene DCAF12L2, one in the common ancestor of primates and rodents and another one in the rodent lineage. Intron gain resulted from the origin of new splice variants, and both genes have two transcript forms, one with retained intron and one with the intron spliced out. Evolution of these genes, especially RNF113B, has been very dynamic and has been accompanied by several additional events including parental gene loss, secondary retroposition, and exaptation of transposable elements.
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spelling pubmed-30022452010-12-15 Primate and Rodent Specific Intron Gains and the Origin of Retrogenes with Splice Variants Szcześniak, Michał W Ciomborowska, Joanna Nowak, Witold Rogozin, Igor B Makałowska, Izabela Mol Biol Evol Letters Retroposition, a leading mechanism for gene duplication, is an important process shaping the evolution of genomes. Retrogenes are also involved in the gene structure evolution as a major player in the process of intron deletion. Here, we demonstrate the role of retrogenes in intron gain in mammals. We identified one case of “intronization,” the transformation of exonic sequences into an intron, in the primate specific retrogene RNF113B and two independent “intronization” events in the retrogene DCAF12L2, one in the common ancestor of primates and rodents and another one in the rodent lineage. Intron gain resulted from the origin of new splice variants, and both genes have two transcript forms, one with retained intron and one with the intron spliced out. Evolution of these genes, especially RNF113B, has been very dynamic and has been accompanied by several additional events including parental gene loss, secondary retroposition, and exaptation of transposable elements. Oxford University Press 2011-01 2010-10-01 /pmc/articles/PMC3002245/ /pubmed/20889727 http://dx.doi.org/10.1093/molbev/msq260 Text en Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution 2010. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letters
Szcześniak, Michał W
Ciomborowska, Joanna
Nowak, Witold
Rogozin, Igor B
Makałowska, Izabela
Primate and Rodent Specific Intron Gains and the Origin of Retrogenes with Splice Variants
title Primate and Rodent Specific Intron Gains and the Origin of Retrogenes with Splice Variants
title_full Primate and Rodent Specific Intron Gains and the Origin of Retrogenes with Splice Variants
title_fullStr Primate and Rodent Specific Intron Gains and the Origin of Retrogenes with Splice Variants
title_full_unstemmed Primate and Rodent Specific Intron Gains and the Origin of Retrogenes with Splice Variants
title_short Primate and Rodent Specific Intron Gains and the Origin of Retrogenes with Splice Variants
title_sort primate and rodent specific intron gains and the origin of retrogenes with splice variants
topic Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002245/
https://www.ncbi.nlm.nih.gov/pubmed/20889727
http://dx.doi.org/10.1093/molbev/msq260
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