Cargando…

A Novel Dimeric Inhibitor Targeting Beta2GPI in Beta2GPI/Antibody Complexes Implicated in Antiphospholipid Syndrome

BACKGROUND: β2GPI is a major antigen for autoantibodies associated with antiphospholipid syndrome (APS), an autoimmune disease characterized by thrombosis and recurrent pregnancy loss. Only the dimeric form of β2GPI generated by anti-β2GPI antibodies is pathologically important, in contrast to monom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kolyada, Alexey, Lee, Chang-Jin, De Biasio, Alfredo, Beglova, Natalia
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002267/ https://www.ncbi.nlm.nih.gov/pubmed/21179511 http://dx.doi.org/10.1371/journal.pone.0015345

Ejemplares similares

Oxidation of beta(2)-glycoprotein I (beta(2)GPI) by the hydroxyl radical alters phospholipid binding and modulates recognition by anti-beta(2)GPI autoantibodies
por: Arvieux, J, et al.
Publicado: (2001)

Dimerized Domain V of Beta2-Glycoprotein I Is Sufficient to Upregulate Procoagulant Activity in PMA-Treated U937 Monocytes and Require Intact Residues in Two Phospholipid-Binding Loops
por: Kolyada, Alexey, et al.
Publicado: (2017)

Hydroxychloroquine partially prevents endothelial dysfunction induced by anti-beta-2-GPI antibodies in an in vivo mouse model of antiphospholipid syndrome
por: Urbanski, Geoffrey, et al.
Publicado: (2018)

PredGPI: a GPI-anchor predictor
por: Pierleoni, Andrea, et al.
Publicado: (2008)

GPI-anchor and GPI-anchored protein expression in PMM2-CDG patients
por: de la Morena-Barrio, Maria E, et al.
Publicado: (2013)

Improving an anti-beta(2) GPI ELISA by reducing the influence of a blocking agent
por: Ambrozic, A, et al.
Publicado: (2001)

The Role of TLR4 on B Cell Activation and Anti-β (2)GPI Antibody Production in the Antiphospholipid Syndrome
por: Cheng, Si, et al.
Publicado: (2016)

The infectious origin of the antiphospholipid syndrome: induction by passive transfer of anti-β2GPI antibodies induced by common bacteria
por: Blank, M, et al.
Publicado: (2003)

Determinants of GPI-PLC Localisation to the Flagellum and Access to GPI-Anchored Substrates in Trypanosomes
por: Sunter, Jack, et al.
Publicado: (2013)

Anti‐β2GPI/β2GPI induces human neutrophils to generate NETs by relying on ROS
por: You, Yanqiu, et al.
Publicado: (2019)

FT-GPI, a highly sensitive and accurate predictor of GPI-anchored proteins, reveals the composition and evolution of the GPI proteome in Plasmodium species
por: Sauer, Lena M., et al.
Publicado: (2023)

Isolation of beta2GPI by perchloric acid yields three proteins having different antigenic properties
por: Cucnik, S, et al.
Publicado: (2001)

A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways
Publicado: (1994)

Accumulated precursors of specific GPI-anchored proteins upregulate GPI biosynthesis with ARV1
por: Liu, Yi-Shi, et al.
Publicado: (2023)

Pro-atherogenic activation of A7r5 cells induced by the oxLDL/β(2)GPI/anti-β(2)GPI complex
por: Wang, Ting, et al.
Publicado: (2018)

Structural analysis of the GPI glycan
por: Nakano, Miyako, et al.
Publicado: (2021)

GPI anchors: Regulated as needed
por: Aguilera-Romero, Auxiliadora, et al.
Publicado: (2023)

Identification of the glycosylphosphatidylinositol-specific phospholipase A2 (GPI-PLA2) that mediates GPI fatty acid remodeling in Trypanosoma brucei
por: Ji, Zhe, et al.
Publicado: (2023)

Domain I of β2GPI is capable of blocking serum IgA antiphospholipid antibodies binding in vitro: an effect enhanced by PEGylation
por: Albay, A, et al.
Publicado: (2019)

Specific inhibition of GPI-anchored protein function by homing and self-association of specific GPI anchors
por: Nicholson, Thomas B., et al.
Publicado: (2006)

A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins
por: Liu, Si-Si, et al.
Publicado: (2021)

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei
por: Jenni, Aurelio, et al.
Publicado: (2021)

Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI
por: Fujita, Morihisa, et al.
Publicado: (2011)

Anti-β2GPI-domain I antibody is associated with extra-criteria manifestations in a large prospective antiphospholipid syndrome cohort in China
por: Zhou, Yangzhong, et al.
Publicado: (2023)

The infectious origin of the antiphospholipid syndrome: induction by passive transfer of anti- β2GPI Abs induced by common bacteria
por: Blank, M, et al.
Publicado: (2001)

Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome
por: Peng, Li, et al.
Publicado: (2022)

Determination of the lipid composition of the GPI anchor
por: Aguilera-Romero, Auxiliadora, et al.
Publicado: (2021)

Lamin is essential for nuclear localization of the GPI synthesis enzyme PIG-B and GPI-anchored protein production in Drosophila
por: Yamamoto-Hino, Miki, et al.
Publicado: (2020)

Platelets activated by the anti-β2GPI/β2GPI complex release microRNAs to inhibit migration and tube formation of human umbilical vein endothelial cells
por: Zhang, Yanfen, et al.
Publicado: (2018)

OxLDL/β2GPI/anti-β2GPI Ab complex induces inflammatory activation via the TLR4/NF-κB pathway in HUVECs
por: Zhang, Guiting, et al.
Publicado: (2021)

Anti-β(2)GPI/β(2)GPI induces neutrophil pyroptosis and thereby enhances ICAM-1 and IL-8 expression in endothelial cells
por: Luo, Jie, et al.
Publicado: (2022)

Retracted: Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome
por: and Alternative Medicine, Evidence-Based Complementary
Publicado: (2023)

Modulation of azole sensitivity and filamentation by GPI15, encoding a subunit of the first GPI biosynthetic enzyme, in Candida albicans
por: Jain, Priyanka, et al.
Publicado: (2019)

Limited ER quality control for GPI-anchored proteins
por: Sikorska, Natalia, et al.
Publicado: (2016)

Effect of the GPI anchor of human Thy-1 on antibody recognition and function
por: Bradley, John E., et al.
Publicado: (2013)

A Case of Juvenile G.P.I
por: Stewart, H. Hilton
Publicado: (1937)

Controversy fuels trafficking of GPI-anchored proteins
por: Schuck, Sebastian, et al.
Publicado: (2006)

Enzymatic mechanism of GPI anchor attachment clarified
por: Kinoshita, Taroh
Publicado: (2014)

Chiara Zurzolo: GPI knows the way to go
por: Sedwick, Caitlin
Publicado: (2015)

Endoplasmic Reticulum Export of GPI-Anchored Proteins
por: Lopez, Sergio, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_pvi6f5s0ond0g4c4qr5mhifpdn