Proteochemometric Modeling of the Susceptibility of Mutated Variants of the HIV-1 Virus to Reverse Transcriptase Inhibitors

BACKGROUND: Reverse transcriptase is a major drug target in highly active antiretroviral therapy (HAART) against HIV, which typically comprises two nucleoside/nucleotide analog reverse transcriptase (RT) inhibitors (NRTIs) in combination with a non-nucleoside RT inhibitor or a protease inhibitor. Un...

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Detalles Bibliográficos
Autores principales: Junaid, Muhammad, Lapins, Maris, Eklund, Martin, Spjuth, Ola, Wikberg, Jarl E. S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002298/
https://www.ncbi.nlm.nih.gov/pubmed/21179544
http://dx.doi.org/10.1371/journal.pone.0014353

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