Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection

BACKGROUND: Host determinants of HIV-1 viral tropism include factors from producer cells that affect the efficiency of productive infection and factors in target cells that block infection after viral entry. TRIM5α restricts HIV-1 infection at an early post-entry step through a mechanism associated...

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Detalles Bibliográficos
Autores principales: Khurana, Bharat, Zhuang, Lei, Moitra, Prasun K, Stantchev, Tzanko S, Broder, Christopher C, Cutler, Mary Lou, D'Arpa, Peter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002306/
https://www.ncbi.nlm.nih.gov/pubmed/21092135
http://dx.doi.org/10.1186/1743-422X-7-332

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