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Zinc in innate and adaptive tumor immunity

Zinc is important. It is the second most abundant trace metal with 2-4 grams in humans. It is an essential trace element, critical for cell growth, development and differentiation, DNA synthesis, RNA transcription, cell division, and cell activation. Zinc deficiency has adverse consequences during e...

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Autores principales: John, Erica, Laskow, Thomas C, Buchser, William J, Pitt, Bruce R, Basse, Per H, Butterfield, Lisa H, Kalinski, Pawel, Lotze, Michael T
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002329/
https://www.ncbi.nlm.nih.gov/pubmed/21087493
http://dx.doi.org/10.1186/1479-5876-8-118
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author John, Erica
Laskow, Thomas C
Buchser, William J
Pitt, Bruce R
Basse, Per H
Butterfield, Lisa H
Kalinski, Pawel
Lotze, Michael T
author_facet John, Erica
Laskow, Thomas C
Buchser, William J
Pitt, Bruce R
Basse, Per H
Butterfield, Lisa H
Kalinski, Pawel
Lotze, Michael T
author_sort John, Erica
collection PubMed
description Zinc is important. It is the second most abundant trace metal with 2-4 grams in humans. It is an essential trace element, critical for cell growth, development and differentiation, DNA synthesis, RNA transcription, cell division, and cell activation. Zinc deficiency has adverse consequences during embryogenesis and early childhood development, particularly on immune functioning. It is essential in members of all enzyme classes, including over 300 signaling molecules and transcription factors. Free zinc in immune and tumor cells is regulated by 14 distinct zinc importers (ZIP) and transporters (ZNT1-8). Zinc depletion induces cell death via apoptosis (or necrosis if apoptotic pathways are blocked) while sufficient zinc levels allows maintenance of autophagy. Cancer cells have upregulated zinc importers, and frequently increased zinc levels, which allow them to survive. Based on this novel synthesis, approaches which locally regulate zinc levels to promote survival of immune cells and/or induce tumor apoptosis are in order.
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spelling pubmed-30023292010-12-16 Zinc in innate and adaptive tumor immunity John, Erica Laskow, Thomas C Buchser, William J Pitt, Bruce R Basse, Per H Butterfield, Lisa H Kalinski, Pawel Lotze, Michael T J Transl Med Review Zinc is important. It is the second most abundant trace metal with 2-4 grams in humans. It is an essential trace element, critical for cell growth, development and differentiation, DNA synthesis, RNA transcription, cell division, and cell activation. Zinc deficiency has adverse consequences during embryogenesis and early childhood development, particularly on immune functioning. It is essential in members of all enzyme classes, including over 300 signaling molecules and transcription factors. Free zinc in immune and tumor cells is regulated by 14 distinct zinc importers (ZIP) and transporters (ZNT1-8). Zinc depletion induces cell death via apoptosis (or necrosis if apoptotic pathways are blocked) while sufficient zinc levels allows maintenance of autophagy. Cancer cells have upregulated zinc importers, and frequently increased zinc levels, which allow them to survive. Based on this novel synthesis, approaches which locally regulate zinc levels to promote survival of immune cells and/or induce tumor apoptosis are in order. BioMed Central 2010-11-18 /pmc/articles/PMC3002329/ /pubmed/21087493 http://dx.doi.org/10.1186/1479-5876-8-118 Text en Copyright ©2010 John et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
John, Erica
Laskow, Thomas C
Buchser, William J
Pitt, Bruce R
Basse, Per H
Butterfield, Lisa H
Kalinski, Pawel
Lotze, Michael T
Zinc in innate and adaptive tumor immunity
title Zinc in innate and adaptive tumor immunity
title_full Zinc in innate and adaptive tumor immunity
title_fullStr Zinc in innate and adaptive tumor immunity
title_full_unstemmed Zinc in innate and adaptive tumor immunity
title_short Zinc in innate and adaptive tumor immunity
title_sort zinc in innate and adaptive tumor immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002329/
https://www.ncbi.nlm.nih.gov/pubmed/21087493
http://dx.doi.org/10.1186/1479-5876-8-118
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