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Monilethrix in Pattern Distribution in Siblings: Diagnosis by Trichoscopy

Monilethrix is a heritable hair shaft defect characterized by localized or diffuse alopecia resulting from hair fragility over friction areas, predominantly the temporal and occipital regions, and follicular keratosis over the occipital region. However, it lacks macroscopic features that enable easy...

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Detalles Bibliográficos
Autores principales: Jain, Nilam, Khopkar, Uday
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002417/
https://www.ncbi.nlm.nih.gov/pubmed/21188029
http://dx.doi.org/10.4103/0974-7753.66918
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author Jain, Nilam
Khopkar, Uday
author_facet Jain, Nilam
Khopkar, Uday
author_sort Jain, Nilam
collection PubMed
description Monilethrix is a heritable hair shaft defect characterized by localized or diffuse alopecia resulting from hair fragility over friction areas, predominantly the temporal and occipital regions, and follicular keratosis over the occipital region. However, it lacks macroscopic features that enable easy and rapid diagnosis in medical practice. Hair shaft microscopy is the basis for diagnosing monilethrix. We present a report of two Indian male siblings aged 24 and 21, who presented with thinning and hair loss from the scalp in male pattern distribution and multiple skin-colored follicular papules over the nape of the neck and bilateral forearms since childhood. Trichoscopy of scalp hair revealed characteristic uniform elliptical nodes and intermittent constrictions along with variation in hair shaft diameter, presence of few vellus hair and yellow dots, suggesting a diagnosis of monilethrix with early-onset androgenetic alopecia. Dermoscopy of the papules revealed multiple stubs of broken hair arising from them with a similar beaded appearance, suggesting a diagnosis of monilethrix. The diagnosis of monilethrix was confirmed with light microscopy and hair clipping. This report highlights the patterned distribution of hair loss in monilethrix probably due to the early unmasking of androgenetic alopecia and the use of trichoscopy as the diagnostic modality.
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spelling pubmed-30024172010-12-23 Monilethrix in Pattern Distribution in Siblings: Diagnosis by Trichoscopy Jain, Nilam Khopkar, Uday Int J Trichology Case Report Monilethrix is a heritable hair shaft defect characterized by localized or diffuse alopecia resulting from hair fragility over friction areas, predominantly the temporal and occipital regions, and follicular keratosis over the occipital region. However, it lacks macroscopic features that enable easy and rapid diagnosis in medical practice. Hair shaft microscopy is the basis for diagnosing monilethrix. We present a report of two Indian male siblings aged 24 and 21, who presented with thinning and hair loss from the scalp in male pattern distribution and multiple skin-colored follicular papules over the nape of the neck and bilateral forearms since childhood. Trichoscopy of scalp hair revealed characteristic uniform elliptical nodes and intermittent constrictions along with variation in hair shaft diameter, presence of few vellus hair and yellow dots, suggesting a diagnosis of monilethrix with early-onset androgenetic alopecia. Dermoscopy of the papules revealed multiple stubs of broken hair arising from them with a similar beaded appearance, suggesting a diagnosis of monilethrix. The diagnosis of monilethrix was confirmed with light microscopy and hair clipping. This report highlights the patterned distribution of hair loss in monilethrix probably due to the early unmasking of androgenetic alopecia and the use of trichoscopy as the diagnostic modality. Medknow Publications 2010 /pmc/articles/PMC3002417/ /pubmed/21188029 http://dx.doi.org/10.4103/0974-7753.66918 Text en © International Journal of Trichology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Jain, Nilam
Khopkar, Uday
Monilethrix in Pattern Distribution in Siblings: Diagnosis by Trichoscopy
title Monilethrix in Pattern Distribution in Siblings: Diagnosis by Trichoscopy
title_full Monilethrix in Pattern Distribution in Siblings: Diagnosis by Trichoscopy
title_fullStr Monilethrix in Pattern Distribution in Siblings: Diagnosis by Trichoscopy
title_full_unstemmed Monilethrix in Pattern Distribution in Siblings: Diagnosis by Trichoscopy
title_short Monilethrix in Pattern Distribution in Siblings: Diagnosis by Trichoscopy
title_sort monilethrix in pattern distribution in siblings: diagnosis by trichoscopy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002417/
https://www.ncbi.nlm.nih.gov/pubmed/21188029
http://dx.doi.org/10.4103/0974-7753.66918
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