Pharmacophore Elucidation and Molecular Docking Studies on 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid Derivatives as COX-2 Inhibitors

A set of 5-phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic acid derivatives (16–32) showing anti-inflammatory activity was analyzed using a three-dimensional qualitative structure-selectivity relationship (3D QSSR) method. The CatalystHipHop approach was used to generate a pharmacophore model fo...

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Detalles Bibliográficos
Autores principales: Lindner, Marc, Sippl, Wolfgang, Radwan, Awwad A.
Formato: Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2010
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002798/
https://www.ncbi.nlm.nih.gov/pubmed/21179343
http://dx.doi.org/10.3797/scipharm.0912-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002798/
https://www.ncbi.nlm.nih.gov/pubmed/21179343
http://dx.doi.org/10.3797/scipharm.0912-19

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