Production, Quality Control and Pharmacokinetic Studies of (166)Ho-EDTMP for Therapeutic Applications

(166)Ho-EDTMP is a major therapeutic agent which is widely used in bone palliation therapy. In this study, a (166)Ho-EDTMP complex was prepared successfully using an in-house synthesized EDTMP ligand and (166)HoCl(3). Ho-166 chloride was obtained by thermal neutron irradiation (1 × 10(13) ncm(−2)s(−...

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Autores principales: Bahrami-Samani, Ali, Bagheri, Reza, Jalilian, Amir R., Shirvani-Arani, Simindokht, Ghannadi-Maragheh, Mohammad, Shamsaee, Mojtaba
Formato: Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2010
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002809/
https://www.ncbi.nlm.nih.gov/pubmed/21179355
http://dx.doi.org/10.3797/scipharm.1004-21
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author Bahrami-Samani, Ali
Bagheri, Reza
Jalilian, Amir R.
Shirvani-Arani, Simindokht
Ghannadi-Maragheh, Mohammad
Shamsaee, Mojtaba
author_facet Bahrami-Samani, Ali
Bagheri, Reza
Jalilian, Amir R.
Shirvani-Arani, Simindokht
Ghannadi-Maragheh, Mohammad
Shamsaee, Mojtaba
author_sort Bahrami-Samani, Ali
collection PubMed
description (166)Ho-EDTMP is a major therapeutic agent which is widely used in bone palliation therapy. In this study, a (166)Ho-EDTMP complex was prepared successfully using an in-house synthesized EDTMP ligand and (166)HoCl(3). Ho-166 chloride was obtained by thermal neutron irradiation (1 × 10(13) ncm(−2)s(−1)) of natural Ho(NO(3))(3) samples (specific activity = 3–5 GBq/mg), dissolved in acidic media. The radiochemical purity of (166)Ho-EDTMP was checked by ITLC (>99%) and stability studies in presence of human serum and final preparation were performed. The biodistribution of (166)Ho-EDTMP and (166)HoCl(3) in wild-type rats was checked by scarification. SPECT imaging of (166)Ho-EDTMP was also performed in wild-type rats. A comparative accumulation study for (166)Ho-EDTMP and (166)HoCl(3) was performed for vital organs up to 48h. Significant bone accumulation (>70%) of the tracer in 48h was observed.
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spelling pubmed-30028092010-12-22 Production, Quality Control and Pharmacokinetic Studies of (166)Ho-EDTMP for Therapeutic Applications Bahrami-Samani, Ali Bagheri, Reza Jalilian, Amir R. Shirvani-Arani, Simindokht Ghannadi-Maragheh, Mohammad Shamsaee, Mojtaba Sci Pharm Original Papers (166)Ho-EDTMP is a major therapeutic agent which is widely used in bone palliation therapy. In this study, a (166)Ho-EDTMP complex was prepared successfully using an in-house synthesized EDTMP ligand and (166)HoCl(3). Ho-166 chloride was obtained by thermal neutron irradiation (1 × 10(13) ncm(−2)s(−1)) of natural Ho(NO(3))(3) samples (specific activity = 3–5 GBq/mg), dissolved in acidic media. The radiochemical purity of (166)Ho-EDTMP was checked by ITLC (>99%) and stability studies in presence of human serum and final preparation were performed. The biodistribution of (166)Ho-EDTMP and (166)HoCl(3) in wild-type rats was checked by scarification. SPECT imaging of (166)Ho-EDTMP was also performed in wild-type rats. A comparative accumulation study for (166)Ho-EDTMP and (166)HoCl(3) was performed for vital organs up to 48h. Significant bone accumulation (>70%) of the tracer in 48h was observed. Österreichische Apotheker-Verlagsgesellschaft 2010 2010-06-09 /pmc/articles/PMC3002809/ /pubmed/21179355 http://dx.doi.org/10.3797/scipharm.1004-21 Text en © Bahrami-Samani et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
Bahrami-Samani, Ali
Bagheri, Reza
Jalilian, Amir R.
Shirvani-Arani, Simindokht
Ghannadi-Maragheh, Mohammad
Shamsaee, Mojtaba
Production, Quality Control and Pharmacokinetic Studies of (166)Ho-EDTMP for Therapeutic Applications
title Production, Quality Control and Pharmacokinetic Studies of (166)Ho-EDTMP for Therapeutic Applications
title_full Production, Quality Control and Pharmacokinetic Studies of (166)Ho-EDTMP for Therapeutic Applications
title_fullStr Production, Quality Control and Pharmacokinetic Studies of (166)Ho-EDTMP for Therapeutic Applications
title_full_unstemmed Production, Quality Control and Pharmacokinetic Studies of (166)Ho-EDTMP for Therapeutic Applications
title_short Production, Quality Control and Pharmacokinetic Studies of (166)Ho-EDTMP for Therapeutic Applications
title_sort production, quality control and pharmacokinetic studies of (166)ho-edtmp for therapeutic applications
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002809/
https://www.ncbi.nlm.nih.gov/pubmed/21179355
http://dx.doi.org/10.3797/scipharm.1004-21
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