MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease

Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress...

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Autores principales: Yao, Jiaqi, Hennessey, Tom, Flynt, Alex, Lai, Eric, Beal, M. Flint, Lin, Michael T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002958/
https://www.ncbi.nlm.nih.gov/pubmed/21179570
http://dx.doi.org/10.1371/journal.pone.0015546
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author Yao, Jiaqi
Hennessey, Tom
Flynt, Alex
Lai, Eric
Beal, M. Flint
Lin, Michael T.
author_facet Yao, Jiaqi
Hennessey, Tom
Flynt, Alex
Lai, Eric
Beal, M. Flint
Lin, Michael T.
author_sort Yao, Jiaqi
collection PubMed
description Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD. These results suggest that microRNAs may play an important role in cytoskeletal pathology in AD.
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spelling pubmed-30029582010-12-21 MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease Yao, Jiaqi Hennessey, Tom Flynt, Alex Lai, Eric Beal, M. Flint Lin, Michael T. PLoS One Research Article Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD. These results suggest that microRNAs may play an important role in cytoskeletal pathology in AD. Public Library of Science 2010-12-16 /pmc/articles/PMC3002958/ /pubmed/21179570 http://dx.doi.org/10.1371/journal.pone.0015546 Text en Yao et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yao, Jiaqi
Hennessey, Tom
Flynt, Alex
Lai, Eric
Beal, M. Flint
Lin, Michael T.
MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease
title MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease
title_full MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease
title_fullStr MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease
title_full_unstemmed MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease
title_short MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease
title_sort microrna-related cofilin abnormality in alzheimer's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002958/
https://www.ncbi.nlm.nih.gov/pubmed/21179570
http://dx.doi.org/10.1371/journal.pone.0015546
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AT bealmflint micrornarelatedcofilinabnormalityinalzheimersdisease
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