Selective Induction of DNA Repair Pathways in Human B Cells Activated by CD4(+) T Cells

Greater than 75% of all hematologic malignancies derive from germinal center (GC) or post-GC B cells, suggesting that the GC reaction predisposes B cells to tumorigenesis. Because GC B cells acquire expression of the highly mutagenic enzyme activation-induced cytidine deaminase (AID), GC B cells may...

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Detalles Bibliográficos
Autores principales: Wu, Xiaosheng, Tschumper, Renee C., Gutierrez, Albert, Mihalcik, Stephen A., Nowakowski, Grzegorz S., Jelinek, Diane F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002972/
https://www.ncbi.nlm.nih.gov/pubmed/21179576
http://dx.doi.org/10.1371/journal.pone.0015549

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