Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria

Brain accumulation of the amyloid-β peptide (Aβ) and oxidative stress underlie neuronal dysfunction and memory loss in Alzheimer's disease (AD). Hexokinase (HK), a key glycolytic enzyme, plays important pro-survival roles, reducing mitochondrial reactive oxygen species (ROS) generation and prev...

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Detalles Bibliográficos
Autores principales: Saraiva, Leonardo M., Seixas da Silva, Gisele S., Galina, Antonio, da-Silva, Wagner S., Klein, William L., Ferreira, Sérgio T., De Felice, Fernanda G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002973/
https://www.ncbi.nlm.nih.gov/pubmed/21179577
http://dx.doi.org/10.1371/journal.pone.0015230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002973/
https://www.ncbi.nlm.nih.gov/pubmed/21179577
http://dx.doi.org/10.1371/journal.pone.0015230

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