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A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

Decades of study have revealed more than 100 ribonucleoside structures incorporated as post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional dynamics of this conserved system are unclear. To this end, we developed a highly precise mass spectrometric method to quantify...

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Detalles Bibliográficos
Autores principales: Chan, Clement T. Y., Dyavaiah, Madhu, DeMott, Michael S., Taghizadeh, Koli, Dedon, Peter C., Begley, Thomas J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002981/
https://www.ncbi.nlm.nih.gov/pubmed/21187895
http://dx.doi.org/10.1371/journal.pgen.1001247

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