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A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress
Decades of study have revealed more than 100 ribonucleoside structures incorporated as post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional dynamics of this conserved system are unclear. To this end, we developed a highly precise mass spectrometric method to quantify...
Autores principales: | Chan, Clement T. Y., Dyavaiah, Madhu, DeMott, Michael S., Taghizadeh, Koli, Dedon, Peter C., Begley, Thomas J. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002981/ https://www.ncbi.nlm.nih.gov/pubmed/21187895 http://dx.doi.org/10.1371/journal.pgen.1001247 |
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