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Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin

Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation meth...

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Autores principales: Sapkal, Nidhi P., Kilor, Vaishali A., Shewale, Bharti D., Bhusari, K. P., Daud, A. S.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003164/
https://www.ncbi.nlm.nih.gov/pubmed/21188040
http://dx.doi.org/10.4103/0250-474X.70477
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author Sapkal, Nidhi P.
Kilor, Vaishali A.
Shewale, Bharti D.
Bhusari, K. P.
Daud, A. S.
author_facet Sapkal, Nidhi P.
Kilor, Vaishali A.
Shewale, Bharti D.
Bhusari, K. P.
Daud, A. S.
author_sort Sapkal, Nidhi P.
collection PubMed
description Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spectroscopy, X-ray diffractometry, and in vitro dissolution studies. Fexofenadine was found to exhibit interaction with β-cyclodextrin both in solid and liquid state. Phase solubility studies indicated that fexofenadine forms a stable complex with β-cyclodextrin. Both IR spectroscopy and X-ray diffractometry studies indicated interaction of fexofenadine with β-cyclodextrin. Kneading method at 1:1 and co-precipitation method at 1:1 and 1:2 molar ratios showed significant interaction. In vitro dissolution studies confirmed the same results.
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spelling pubmed-30031642010-12-23 Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin Sapkal, Nidhi P. Kilor, Vaishali A. Shewale, Bharti D. Bhusari, K. P. Daud, A. S. Indian J Pharm Sci Research Paper Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spectroscopy, X-ray diffractometry, and in vitro dissolution studies. Fexofenadine was found to exhibit interaction with β-cyclodextrin both in solid and liquid state. Phase solubility studies indicated that fexofenadine forms a stable complex with β-cyclodextrin. Both IR spectroscopy and X-ray diffractometry studies indicated interaction of fexofenadine with β-cyclodextrin. Kneading method at 1:1 and co-precipitation method at 1:1 and 1:2 molar ratios showed significant interaction. In vitro dissolution studies confirmed the same results. Medknow Publications 2010 /pmc/articles/PMC3003164/ /pubmed/21188040 http://dx.doi.org/10.4103/0250-474X.70477 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Sapkal, Nidhi P.
Kilor, Vaishali A.
Shewale, Bharti D.
Bhusari, K. P.
Daud, A. S.
Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin
title Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin
title_full Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin
title_fullStr Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin
title_full_unstemmed Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin
title_short Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin
title_sort study of the complexation behaviour of fexofenadine with β-cyclodextrin
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003164/
https://www.ncbi.nlm.nih.gov/pubmed/21188040
http://dx.doi.org/10.4103/0250-474X.70477
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