Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones

Schiff bases (9a-l) of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4-(3H)-ones (8) with various substituted aldehydes were obtained by refluxing 1:1 molar equivalents of the reactants in dry ethanol for 6 h. The aminoquinazoline (8) was inturn obtained from 3,5-dibromoantharlinic acid via intermediate (...

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Autores principales: Paneersalvam, P., Raj, T., Ishar, M. P. S., Singh, B., Sharma, V., Rather, B. A.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003175/
https://www.ncbi.nlm.nih.gov/pubmed/21188051
http://dx.doi.org/10.4103/0250-474X.70488
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author Paneersalvam, P.
Raj, T.
Ishar, M. P. S.
Singh, B.
Sharma, V.
Rather, B. A.
author_facet Paneersalvam, P.
Raj, T.
Ishar, M. P. S.
Singh, B.
Sharma, V.
Rather, B. A.
author_sort Paneersalvam, P.
collection PubMed
description Schiff bases (9a-l) of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4-(3H)-ones (8) with various substituted aldehydes were obtained by refluxing 1:1 molar equivalents of the reactants in dry ethanol for 6 h. The aminoquinazoline (8) was inturn obtained from 3,5-dibromoantharlinic acid via intermediate (7). All the synthesized compounds (9a-l) were evaluated for their anticonvulsant activity on albino mice by maximal electroshock method using phenytoin as a standard. The compound (9l) bearing a cinnamyl function displays a very high activity (82.74 %) at dose level of 100 mg/kg b.w.
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spelling pubmed-30031752010-12-23 Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones Paneersalvam, P. Raj, T. Ishar, M. P. S. Singh, B. Sharma, V. Rather, B. A. Indian J Pharm Sci Short Communication Schiff bases (9a-l) of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4-(3H)-ones (8) with various substituted aldehydes were obtained by refluxing 1:1 molar equivalents of the reactants in dry ethanol for 6 h. The aminoquinazoline (8) was inturn obtained from 3,5-dibromoantharlinic acid via intermediate (7). All the synthesized compounds (9a-l) were evaluated for their anticonvulsant activity on albino mice by maximal electroshock method using phenytoin as a standard. The compound (9l) bearing a cinnamyl function displays a very high activity (82.74 %) at dose level of 100 mg/kg b.w. Medknow Publications 2010 /pmc/articles/PMC3003175/ /pubmed/21188051 http://dx.doi.org/10.4103/0250-474X.70488 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Paneersalvam, P.
Raj, T.
Ishar, M. P. S.
Singh, B.
Sharma, V.
Rather, B. A.
Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones
title Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones
title_full Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones
title_fullStr Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones
title_full_unstemmed Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones
title_short Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones
title_sort anticonvulsant activity of schiff bases of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4(3h)-ones
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003175/
https://www.ncbi.nlm.nih.gov/pubmed/21188051
http://dx.doi.org/10.4103/0250-474X.70488
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