Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications

We have reported previously that reactive-site mutants of N-TIMP-3 [N-terminal inhibitory domain of TIMP-3 (tissue inhibitor of metalloproteinases 3)] modified at the N-terminus, selectively inhibited ADAM17 (a disintegrin and metalloproteinase 17) over the MMPs (matrix metalloproteinases). The prim...

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Detalles Bibliográficos
Autores principales: Lim, Ngee H., Kashiwagi, Masahide, Visse, Robert, Jones, Jonathan, Enghild, Jan J., Brew, Keith, Nagase, Hideaki
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003256/
https://www.ncbi.nlm.nih.gov/pubmed/20645923
http://dx.doi.org/10.1042/BJ20100725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003256/
https://www.ncbi.nlm.nih.gov/pubmed/20645923
http://dx.doi.org/10.1042/BJ20100725

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