Palmitoylation-dependent association with CD63 targets the Ca(2+) sensor synaptotagmin VII to lysosomes

Syt VII is a Ca(2+) sensor that regulates lysosome exocytosis and plasma membrane repair. Because it lacks motifs that mediate lysosomal targeting, it is unclear how Syt VII traffics to these organelles. In this paper, we show that mutations or inhibitors that abolish palmitoylation disrupt Syt VII...

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Detalles Bibliográficos
Autores principales: Flannery, Andrew R., Czibener, Cecilia, Andrews, Norma W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003310/
https://www.ncbi.nlm.nih.gov/pubmed/21041449
http://dx.doi.org/10.1083/jcb.201003021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003310/
https://www.ncbi.nlm.nih.gov/pubmed/21041449
http://dx.doi.org/10.1083/jcb.201003021

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