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Arginine 104 Is a Key Catalytic Residue in Leukotriene C(4) Synthase

Human leukotriene C(4) synthase (hLTC(4)S) is an integral membrane enzyme that conjugates leukotriene (LT) A(4) with glutathione to form LTC(4), a precursor to the cysteinyl leukotrienes (LTC(4), LTD(4), and LTE(4)) that are involved in the pathogenesis of human bronchial asthma. From the crystal st...

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Detalles Bibliográficos
Autores principales:	Rinaldo-Matthis, Agnes, Wetterholm, Anders, Molina, Daniel Martinez, Holm, Johanna, Niegowski, Damian, Ohlson, Eva, Nordlund, Pär, Morgenstern, Ralf, Haeggström, Jesper Z.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003377/ https://www.ncbi.nlm.nih.gov/pubmed/20980252 http://dx.doi.org/10.1074/jbc.M110.105940

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