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Treatment of Lyme borreliosis
Borrelia burgdorferi sensu lato is the causative agent of Lyme borreliosis in humans. This inflammatory disease can affect the skin, the peripheral and central nervous system, the musculoskeletal and cardiovascular system and rarely the eyes. Early stages are directly associated with viable bacteria...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003502/ https://www.ncbi.nlm.nih.gov/pubmed/20067594 http://dx.doi.org/10.1186/ar2853 |
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author | Girschick, Hermann J Morbach, Henner Tappe, Dennis |
author_facet | Girschick, Hermann J Morbach, Henner Tappe, Dennis |
author_sort | Girschick, Hermann J |
collection | PubMed |
description | Borrelia burgdorferi sensu lato is the causative agent of Lyme borreliosis in humans. This inflammatory disease can affect the skin, the peripheral and central nervous system, the musculoskeletal and cardiovascular system and rarely the eyes. Early stages are directly associated with viable bacteria at the site of inflammation. The pathogen-host interaction is complex and has been elucidated only in part. B. burgdorferi is highly susceptible to antibiotic treatment and the majority of patients profit from this treatment. Some patients develop chronic persistent disease despite repeated antibiotics. Whether this is a sequel of pathogen persistence or a status of chronic auto-inflammation, auto-immunity or a form of fibromyalgia is highly debated. Since vaccination is not available, prevention of a tick bite or chemoprophylaxis is important. If the infection is manifest, then treatment strategies should target not only the pathogen by using antibiotics but also the chronic inflammation by using anti-inflammatory drugs. |
format | Text |
id | pubmed-3003502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30035022010-12-18 Treatment of Lyme borreliosis Girschick, Hermann J Morbach, Henner Tappe, Dennis Arthritis Res Ther Review Borrelia burgdorferi sensu lato is the causative agent of Lyme borreliosis in humans. This inflammatory disease can affect the skin, the peripheral and central nervous system, the musculoskeletal and cardiovascular system and rarely the eyes. Early stages are directly associated with viable bacteria at the site of inflammation. The pathogen-host interaction is complex and has been elucidated only in part. B. burgdorferi is highly susceptible to antibiotic treatment and the majority of patients profit from this treatment. Some patients develop chronic persistent disease despite repeated antibiotics. Whether this is a sequel of pathogen persistence or a status of chronic auto-inflammation, auto-immunity or a form of fibromyalgia is highly debated. Since vaccination is not available, prevention of a tick bite or chemoprophylaxis is important. If the infection is manifest, then treatment strategies should target not only the pathogen by using antibiotics but also the chronic inflammation by using anti-inflammatory drugs. BioMed Central 2009 2009-12-17 /pmc/articles/PMC3003502/ /pubmed/20067594 http://dx.doi.org/10.1186/ar2853 Text en Copyright ©2009 BioMed Central Ltd. |
spellingShingle | Review Girschick, Hermann J Morbach, Henner Tappe, Dennis Treatment of Lyme borreliosis |
title | Treatment of Lyme borreliosis |
title_full | Treatment of Lyme borreliosis |
title_fullStr | Treatment of Lyme borreliosis |
title_full_unstemmed | Treatment of Lyme borreliosis |
title_short | Treatment of Lyme borreliosis |
title_sort | treatment of lyme borreliosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003502/ https://www.ncbi.nlm.nih.gov/pubmed/20067594 http://dx.doi.org/10.1186/ar2853 |
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