Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies

The complete nucleotide sequences of three chimpanzee polyomavirus genetic variants were determined. Phylogenetic analysis indicated that the viruses form two different genotypes of ChPyV. Comparison with other primate polyomaviruses revealed a putative agnogene, and an unusually long VP1 open readi...

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Autores principales: Deuzing, Ilona, Fagrouch, Zahra, Groenewoud, Marlous J, Niphuis, Henk, Kondova, Ivanela, Bogers, Willy, Verschoor, Ernst J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003640/
https://www.ncbi.nlm.nih.gov/pubmed/21110837
http://dx.doi.org/10.1186/1743-422X-7-347
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author Deuzing, Ilona
Fagrouch, Zahra
Groenewoud, Marlous J
Niphuis, Henk
Kondova, Ivanela
Bogers, Willy
Verschoor, Ernst J
author_facet Deuzing, Ilona
Fagrouch, Zahra
Groenewoud, Marlous J
Niphuis, Henk
Kondova, Ivanela
Bogers, Willy
Verschoor, Ernst J
author_sort Deuzing, Ilona
collection PubMed
description The complete nucleotide sequences of three chimpanzee polyomavirus genetic variants were determined. Phylogenetic analysis indicated that the viruses form two different genotypes of ChPyV. Comparison with other primate polyomaviruses revealed a putative agnogene, and an unusually long VP1 open reading frame. The transcriptional control regions (TCR) of the viruses were extremely short (155 nucleotides), and highly conserved amongst the genotypes. Analysis of the TCR from different chimpanzee subspecies, and from a series of tissues from five individuals confirmed its genetic stability, and also indicates that double-infections with different genotypes can occur.
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spelling pubmed-30036402010-12-18 Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies Deuzing, Ilona Fagrouch, Zahra Groenewoud, Marlous J Niphuis, Henk Kondova, Ivanela Bogers, Willy Verschoor, Ernst J Virol J Short Report The complete nucleotide sequences of three chimpanzee polyomavirus genetic variants were determined. Phylogenetic analysis indicated that the viruses form two different genotypes of ChPyV. Comparison with other primate polyomaviruses revealed a putative agnogene, and an unusually long VP1 open reading frame. The transcriptional control regions (TCR) of the viruses were extremely short (155 nucleotides), and highly conserved amongst the genotypes. Analysis of the TCR from different chimpanzee subspecies, and from a series of tissues from five individuals confirmed its genetic stability, and also indicates that double-infections with different genotypes can occur. BioMed Central 2010-11-26 /pmc/articles/PMC3003640/ /pubmed/21110837 http://dx.doi.org/10.1186/1743-422X-7-347 Text en Copyright ©2010 Deuzing et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Deuzing, Ilona
Fagrouch, Zahra
Groenewoud, Marlous J
Niphuis, Henk
Kondova, Ivanela
Bogers, Willy
Verschoor, Ernst J
Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies
title Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies
title_full Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies
title_fullStr Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies
title_full_unstemmed Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies
title_short Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies
title_sort detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003640/
https://www.ncbi.nlm.nih.gov/pubmed/21110837
http://dx.doi.org/10.1186/1743-422X-7-347
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