Cargando…

β-Amyloid 1-42 Oligomers Impair Function of Human Embryonic Stem Cell-Derived Forebrain Cholinergic Neurons

Cognitive impairment in Alzheimer's disease (AD) patients is associated with a decline in the levels of growth factors, impairment of axonal transport and marked degeneration of basal forebrain cholinergic neurons (BFCNs). Neurogenesis persists in the adult human brain, and the stimulation of r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wicklund, Linn, Leão, Richardson N., Strömberg, Anne-Marie, Mousavi, Malahat, Hovatta, Outi, Nordberg, Agneta, Marutle, Amelia
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003688/ https://www.ncbi.nlm.nih.gov/pubmed/21179413 http://dx.doi.org/10.1371/journal.pone.0015600

Ejemplares similares

Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation
por: Malmsten, Linn, et al.
Publicado: (2014)

Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons
por: Nilbratt, Mats, et al.
Publicado: (2010)

Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs
por: Lilja, Anna M., et al.
Publicado: (2015)

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer’s disease
por: Kadir, Ahmadul, et al.
Publicado: (2011)

Treatment of beta amyloid 1–42 (Aβ(1–42))-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo
por: Kwakowsky, Andrea, et al.
Publicado: (2016)

In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer’s Brain Tissue
por: Ni, Ruiqing, et al.
Publicado: (2021)

Derivation of 30 human embryonic stem cell lines—improving the quality
por: Ström, Susanne, et al.
Publicado: (2010)

(3)H-Deprenyl and (3)H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain
por: Marutle, Amelia, et al.
Publicado: (2013)

Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils
por: Ahmed, Mahiuddin, et al.
Publicado: (2010)

Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs
por: Kumar, Rajnish, et al.
Publicado: (2016)

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study
por: Rodriguez-Vieitez, Elena, et al.
Publicado: (2015)

Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers
por: Novo, Mercedes, et al.
Publicado: (2018)

Glutathione S Transferase Activity in the Basal Forebrain Cholinergic Population
por: Francis, A., et al.
Publicado: (1992)

Complete morphologies of basal forebrain cholinergic neurons in the mouse
por: Wu, Hao, et al.
Publicado: (2014)

Corelease of acetylcholine and GABA from cholinergic forebrain neurons
por: Saunders, Arpiar, et al.
Publicado: (2015)

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity
por: Izzo, Nicholas J., et al.
Publicado: (2014)

Oligomer Formation by Amyloid-β42 in a Membrane-Mimicking Environment in Alzheimer’s Disease
por: Rosenberry, Terrone L., et al.
Publicado: (2022)

No Relationship between Embryo Morphology and Successful Derivation of Human Embryonic Stem Cell Lines
por: Ström, Susanne, et al.
Publicado: (2010)

Fast Modulation of Visual Perception by Basal Forebrain Cholinergic Neurons
por: Pinto, Lucas, et al.
Publicado: (2013)

The cholinergic basal forebrain in the ferret and its inputs to the auditory cortex
por: Bajo, Victoria M, et al.
Publicado: (2014)

Basal Forebrain Cholinergic System and Orexin Neurons: Effects on Attention
por: Villano, Ines, et al.
Publicado: (2017)

Cholinergic depletion and basal forebrain volume in primary progressive aphasia
por: Schaeverbeke, Jolien, et al.
Publicado: (2016)

Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation
por: Lehner, Kurt R., et al.
Publicado: (2019)

Basal Forebrain Cholinergic Activity Modulates Isoflurane and Propofol Anesthesia
por: Luo, Tian-Yuan, et al.
Publicado: (2020)

Developmental regulation of GABAergic gene expression in forebrain cholinergic neurons
por: Granger, Adam J., et al.
Publicado: (2023)

Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait
por: Gan, Caiting, et al.
Publicado: (2023)

A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway
por: Nair, Aditya, et al.
Publicado: (2023)

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
por: Lilja, Anna M., et al.
Publicado: (2013)

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits
por: Izzo, Nicholas J., et al.
Publicado: (2014)

Correction: Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
por: Lilja, Anna M., et al.
Publicado: (2013)

Basal Forebrain Cholinergic Deficits Reduce Glucose Metabolism and Function of Cholinergic and GABAergic Systems in the Cingulate Cortex
por: Jeong, Da Un, et al.
Publicado: (2016)

Beta‐amyloid 1‐42 monomers, but not oligomers, produce PHF‐like conformation of Tau protein
por: Manassero, Giusi, et al.
Publicado: (2016)

Amyloid β-peptides 1–40 and 1–42 form oligomers with mixed β-sheets
por: Baldassarre, Maurizio, et al.
Publicado: (2017)

Hippocampal Cholinergic Neurostimulating Peptide as a Possible Modulating Factor against Glutamatergic Neuronal Disability by Amyloid Oligomers
por: Sato, Toyohiro, et al.
Publicado: (2017)

Lesions of the Basal Forebrain Cholinergic System in Mice Disrupt Idiothetic Navigation
por: Hamlin, Adam S., et al.
Publicado: (2013)

Whole-Brain Monosynaptic Afferent Inputs to Basal Forebrain Cholinergic System
por: Hu, Rongfeng, et al.
Publicado: (2016)

Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors
por: Zaghloul, Nahla, et al.
Publicado: (2017)

Subregional volume reduction of the cholinergic forebrain in subjective cognitive decline (SCD)
por: Scheef, Lukas, et al.
Publicado: (2018)

Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors
por: Boskovic, Zoran, et al.
Publicado: (2019)

Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain
por: Allaway, Kathryn C, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_trhh5fhn4uk45isbvo1j77230n