Zinc Overload Enhances APP Cleavage and Aβ Deposition in the Alzheimer Mouse Brain

BACKGROUND: Abnormal zinc homeostasis is involved in β-amyloid (Aβ) plaque formation and, therefore, the zinc load is a contributing factor in Alzheimer's disease (AD). However, the involvement of zinc in amyloid precursor protein (APP) processing and Aβ deposition has not been well established...

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Detalles Bibliográficos
Autores principales: Wang, Chun-Yan, Wang, Tao, Zheng, Wei, Zhao, Bao-Lu, Danscher, Gorm, Chen, Yu-Hua, Wang, Zhan-You
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003690/
https://www.ncbi.nlm.nih.gov/pubmed/21179415
http://dx.doi.org/10.1371/journal.pone.0015349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003690/
https://www.ncbi.nlm.nih.gov/pubmed/21179415
http://dx.doi.org/10.1371/journal.pone.0015349

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