Cargando…

The p16(INK4A) tumor suppressor regulates cellular oxidative stress

Mutations or deletions in the cyclin-dependent kinase inhibitor p16(INK4A) are associated with multiple cancer types, but more commonly found in melanoma tumors and associated with familial melanoma predisposition. Although p16 is thought to function as a tumor suppressor by negatively regulating th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jenkins, Noah C., Liu, Tong, Cassidy, Pamela, Leachman, Sancy A., Boucher, Kenneth M., Goodson, Agnessa Gadeliya, Samadashwily, George, Grossman, Douglas
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003740/ https://www.ncbi.nlm.nih.gov/pubmed/20838381 http://dx.doi.org/10.1038/onc.2010.419

Ejemplares similares

Selenium for the Prevention of Cutaneous Melanoma
por: Cassidy, Pamela B., et al.
Publicado: (2013)

Familial melanoma-associated mutations in p16 uncouple its tumor suppressor functions
por: Jenkins, Noah C., et al.
Publicado: (2012)

Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage
por: Cassidy, Pamela B., et al.
Publicado: (2015)

p16INK4a in cellular senescence
por: Simboeck, Elisabeth, et al.
Publicado: (2013)

The effects of transferring tumor suppressor gene p16(INK4A) to p16(INK4A)-deleted cancer cells*
por: Lee, Kye Young, et al.
Publicado: (1999)

Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences
por: Tramontano, Alfonso, et al.
Publicado: (2020)

Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi
por: Hawkes, Jason E., et al.
Publicado: (2013)

Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16(INK4A)
por: Göbl, Christoph, et al.
Publicado: (2019)

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention
por: Fan, Meiyun, et al.
Publicado: (2013)

Identification, genetic testing, and management of hereditary melanoma
por: Leachman, Sancy A., et al.
Publicado: (2017)

Alterations of tumor suppressor gene p16(INK4a )in pancreatic ductal carcinoma
por: Attri, Jyotika, et al.
Publicado: (2005)

Cellular and ultrastructural characterization of the grey-morph phenotype in southern right whales (Eubalaena australis)
por: Eroh, Guy D., et al.
Publicado: (2017)

Loss of p16(INK4A) stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway
por: Tyagi, Ethika, et al.
Publicado: (2017)

Detection of Exosomal miRNAs in the Plasma of Melanoma Patients
por: Pfeffer, Susan R., et al.
Publicado: (2015)

Reply to Reimann et al.
por: Clarke, Loren E., et al.
Publicado: (2019)

Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice
por: Sato, Seidai, et al.
Publicado: (2015)

Reply to: Comments on “Proposed approach for reusing surgical masks in COVID-19 pandemic”
por: Liu, Yuangang, et al.
Publicado: (2020)

Proposed approach for reusing surgical masks in COVID-19 pandemic
por: Liu, Yuangang, et al.
Publicado: (2020)

Methylation and Immunoexpression of p16(INK4a) Tumor Suppressor Gene in Primary Breast Cancer Tissue and Their Quantitative p16(INK4a) Hypermethylation in Plasma by Real-Time PCR
por: Lee, Jae Jun, et al.
Publicado: (2012)

Cellular senescence mediated by p16(INK4A)-coupled miRNA pathways
por: Overhoff, Marita G., et al.
Publicado: (2014)

The p16(INK4a) tumor suppressor controls p21(WAF1) induction in response to ultraviolet light
por: Al-Mohanna, Mai A., et al.
Publicado: (2007)

The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16(INK4a)
por: Becker, Therese M, et al.
Publicado: (2009)

E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability
por: Fukuyo, Yayoi, et al.
Publicado: (2011)

Loss of p16(Ink4a) Function Rescues Cellular Senescence Induced by Telomere Dysfunction
por: Zhang, Xiufeng, et al.
Publicado: (2012)

p16(INK4a) Regulates Cellular Senescence in PD-1-Expressing Human T Cells
por: Janelle, Valérie, et al.
Publicado: (2021)

From Melanocyte to Malignant Metastatic Melanoma
por: Manga, Prashiela, et al.
Publicado: (2010)

Prognostic gene expression profiling in melanoma: necessary steps to incorporate into clinical practice
por: Grossman, Douglas, et al.
Publicado: (2019)

Aerobic exercise induces tumor suppressor p16(INK4a) expression of endothelial progenitor cells in human skeletal muscle
por: Wu, Jinfu, et al.
Publicado: (2020)

Physical Indicators of Aging are Related to Cellular Senescence Signal P16INK4a in Midlife Adults
por: Rentscher, Kelly, et al.
Publicado: (2021)

CDKN2A testing and genetic counseling promote reductions in objectively measured sun exposure one year later
por: Stump, Tammy K., et al.
Publicado: (2019)

p16(INK4a) Expression in Porokeratosis
por: Uryu, Miki, et al.
Publicado: (2017)

The 5′-untranslated region of p16(INK4a) melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding
por: Bisio, Alessandra, et al.
Publicado: (2015)

Combined Use of Dermoscopy, Reflectance Confocal Microscopy and Ex-Vivo Gene Expression Profiling to Detect a Micro-Melanoma Less Than 1 mm in Diameter
por: Witkowski, Alexander, et al.
Publicado: (2023)

Irreversibility of cellular senescence: dual roles of p16(INK4a)/Rb-pathway in cell cycle control
por: Takahashi, Akiko, et al.
Publicado: (2007)

Loss of heterozygosity of CDKN2A (p16INK4a) and RB1 tumor suppressor genes in testicular germ cell tumors
por: Vladusic, Tomislav, et al.
Publicado: (2010)

The tumour suppressor CDKN2A/p16(INK4a) regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue
por: Wouters, Kristiaan, et al.
Publicado: (2017)

Deletion of the p16(INK4a) tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate
por: Lee, Dong-Hong, et al.
Publicado: (2019)

CDK6 Degradation Is Counteracted by p16(INK4A) and p18(INK4C) in AML
por: Schmalzbauer, Belinda S., et al.
Publicado: (2022)

Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
por: Wiedemeyer, Ruprecht, et al.
Publicado: (2008)

Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species
por: Jenkins, Noah C., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_6fvif6b56psakueutqvkptu6oi