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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) in DNA1,2. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse my...

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Detalles Bibliográficos
Autores principales:	Ko, Myunggon, Huang, Yun, Jankowska, Anna M., Pape, Utz J., Tahiliani, Mamta, Bandukwala, Hozefa S., An, Jungeun, Lamperti, Edward D., Koh, Kian Peng, Ganetzky, Rebecca, Liu, X. Shirley, Aravind, L., Agarwal, Suneet, Maciejewski, Jaroslaw P., Rao, Anjana
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003755/ https://www.ncbi.nlm.nih.gov/pubmed/21057493 http://dx.doi.org/10.1038/nature09586

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