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The DAC system and associations with acute leukemias and myelodysplastic syndromes
Imbalances of histone acetyltransferase (HAT) and deacetylase activity (DAC) that result in deregulated gene expression are commonly observed in leukemias. These alterations provide the basis for novel therapeutic approaches that target the epigenetic mechanisms implicated in leukemogenesis. As the...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003828/ https://www.ncbi.nlm.nih.gov/pubmed/21153858 http://dx.doi.org/10.1007/s10637-010-9595-z |