Concise Review: Stem Cells As an Emerging Platform for Antibody Therapy of Cancer

Monoclonal antibodies are important tools for cancer therapy, however, three factors limit their effectiveness: toxicity, poor tumor penetration, and inability to cross the blood-brain barrier. This review discusses the emerging field of stem cell-mediated antibody delivery and how this approach may...

Descripción completa

Detalles Bibliográficos
Autores principales: Frank, Richard T, Najbauer, Joseph, Aboody, Karen S
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Translational and Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003900/
https://www.ncbi.nlm.nih.gov/pubmed/21089119
http://dx.doi.org/10.1002/stem.513
Descripción
Sumario:Monoclonal antibodies are important tools for cancer therapy, however, three factors limit their effectiveness: toxicity, poor tumor penetration, and inability to cross the blood-brain barrier. This review discusses the emerging field of stem cell-mediated antibody delivery and how this approach may improve antibody therapy of cancer by overcoming these obstacles. STEM CELLS 2010;28:2084–2087

Ejemplares similares