Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach

We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PA...

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Autores principales: Lobbes, M. B. I., Kooi, M. E., Lutgens, E., Ruiters, A. W., Lima Passos, V., Braat, S. H. J. G., Rousch, M., Ten Cate, H., van Engelshoven, J. M. A., Daemen, M. J. A. P., Heeneman, S.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003971/
https://www.ncbi.nlm.nih.gov/pubmed/21188207
http://dx.doi.org/10.1155/2010/726207
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author Lobbes, M. B. I.
Kooi, M. E.
Lutgens, E.
Ruiters, A. W.
Lima Passos, V.
Braat, S. H. J. G.
Rousch, M.
Ten Cate, H.
van Engelshoven, J. M. A.
Daemen, M. J. A. P.
Heeneman, S.
author_facet Lobbes, M. B. I.
Kooi, M. E.
Lutgens, E.
Ruiters, A. W.
Lima Passos, V.
Braat, S. H. J. G.
Rousch, M.
Ten Cate, H.
van Engelshoven, J. M. A.
Daemen, M. J. A. P.
Heeneman, S.
author_sort Lobbes, M. B. I.
collection PubMed
description We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.
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spelling pubmed-30039712010-12-23 Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach Lobbes, M. B. I. Kooi, M. E. Lutgens, E. Ruiters, A. W. Lima Passos, V. Braat, S. H. J. G. Rousch, M. Ten Cate, H. van Engelshoven, J. M. A. Daemen, M. J. A. P. Heeneman, S. Int J Vasc Med Clinical Study We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk. Hindawi Publishing Corporation 2010 2010-05-30 /pmc/articles/PMC3003971/ /pubmed/21188207 http://dx.doi.org/10.1155/2010/726207 Text en Copyright © 2010 M. B. I. Lobbes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Lobbes, M. B. I.
Kooi, M. E.
Lutgens, E.
Ruiters, A. W.
Lima Passos, V.
Braat, S. H. J. G.
Rousch, M.
Ten Cate, H.
van Engelshoven, J. M. A.
Daemen, M. J. A. P.
Heeneman, S.
Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach
title Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach
title_full Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach
title_fullStr Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach
title_full_unstemmed Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach
title_short Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach
title_sort leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: towards a multi-biomarker approach
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003971/
https://www.ncbi.nlm.nih.gov/pubmed/21188207
http://dx.doi.org/10.1155/2010/726207
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