Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi

Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F(2α) from PGH(2) have been determined in the presence or absence of menadione. The binding motif...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Keishi, Okamoto, Naoki, Tokuoka, Keiji, Sugiyama, Shigeru, Uchiyama, Nahoko, Matsumura, Hiroyoshi, Inaka, Koji, Urade, Yoshihiro, Inoue, Tsuyoshi
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Diffraction Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004258/
https://www.ncbi.nlm.nih.gov/pubmed/21169695
http://dx.doi.org/10.1107/S0909049510033595
Descripción
Sumario:Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F(2α) from PGH(2) have been determined in the presence or absence of menadione. The binding motif of menadione, known as one of the inhibitors for TcOYE, should accelerate the structure-based development of novel anti-chagasic drugs that inhibit PGF(2α) production specifically.

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