Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi

Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F(2α) from PGH(2) have been determined in the presence or absence of menadione. The binding motif...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamaguchi, Keishi, Okamoto, Naoki, Tokuoka, Keiji, Sugiyama, Shigeru, Uchiyama, Nahoko, Matsumura, Hiroyoshi, Inaka, Koji, Urade, Yoshihiro, Inoue, Tsuyoshi
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Diffraction Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004258/
https://www.ncbi.nlm.nih.gov/pubmed/21169695
http://dx.doi.org/10.1107/S0909049510033595
_version_ 1782193968015998976
author Yamaguchi, Keishi
Okamoto, Naoki
Tokuoka, Keiji
Sugiyama, Shigeru
Uchiyama, Nahoko
Matsumura, Hiroyoshi
Inaka, Koji
Urade, Yoshihiro
Inoue, Tsuyoshi
author_facet Yamaguchi, Keishi
Okamoto, Naoki
Tokuoka, Keiji
Sugiyama, Shigeru
Uchiyama, Nahoko
Matsumura, Hiroyoshi
Inaka, Koji
Urade, Yoshihiro
Inoue, Tsuyoshi
author_sort Yamaguchi, Keishi
collection PubMed
description Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F(2α) from PGH(2) have been determined in the presence or absence of menadione. The binding motif of menadione, known as one of the inhibitors for TcOYE, should accelerate the structure-based development of novel anti-chagasic drugs that inhibit PGF(2α) production specifically.
format Text
id pubmed-3004258
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-30042582010-12-23 Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi Yamaguchi, Keishi Okamoto, Naoki Tokuoka, Keiji Sugiyama, Shigeru Uchiyama, Nahoko Matsumura, Hiroyoshi Inaka, Koji Urade, Yoshihiro Inoue, Tsuyoshi J Synchrotron Radiat Diffraction Structural Biology Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F(2α) from PGH(2) have been determined in the presence or absence of menadione. The binding motif of menadione, known as one of the inhibitors for TcOYE, should accelerate the structure-based development of novel anti-chagasic drugs that inhibit PGF(2α) production specifically. International Union of Crystallography 2011-01-01 2010-11-12 /pmc/articles/PMC3004258/ /pubmed/21169695 http://dx.doi.org/10.1107/S0909049510033595 Text en © Keishi Yamaguchi et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Diffraction Structural Biology
Yamaguchi, Keishi
Okamoto, Naoki
Tokuoka, Keiji
Sugiyama, Shigeru
Uchiyama, Nahoko
Matsumura, Hiroyoshi
Inaka, Koji
Urade, Yoshihiro
Inoue, Tsuyoshi
Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi
title Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi
title_full Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi
title_fullStr Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi
title_full_unstemmed Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi
title_short Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi
title_sort structure of the inhibitor complex of old yellow enzyme from trypanosoma cruzi
topic Diffraction Structural Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004258/
https://www.ncbi.nlm.nih.gov/pubmed/21169695
http://dx.doi.org/10.1107/S0909049510033595
work_keys_str_mv AT yamaguchikeishi structureoftheinhibitorcomplexofoldyellowenzymefromtrypanosomacruzi
AT okamotonaoki structureoftheinhibitorcomplexofoldyellowenzymefromtrypanosomacruzi
AT tokuokakeiji structureoftheinhibitorcomplexofoldyellowenzymefromtrypanosomacruzi
AT sugiyamashigeru structureoftheinhibitorcomplexofoldyellowenzymefromtrypanosomacruzi
AT uchiyamanahoko structureoftheinhibitorcomplexofoldyellowenzymefromtrypanosomacruzi
AT matsumurahiroyoshi structureoftheinhibitorcomplexofoldyellowenzymefromtrypanosomacruzi
AT inakakoji structureoftheinhibitorcomplexofoldyellowenzymefromtrypanosomacruzi
AT uradeyoshihiro structureoftheinhibitorcomplexofoldyellowenzymefromtrypanosomacruzi
AT inouetsuyoshi structureoftheinhibitorcomplexofoldyellowenzymefromtrypanosomacruzi

Ejemplares similares