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Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery
We compared the efficacy and safety of preemptive vs postoperative dosing of lumiracoxib 400 mg in patients undergoing minor ambulatory arthroscopic knee surgery. Eligible patients were randomized to preemptive lumiracoxib, postoperative lumiracoxib, and placebo. The main efficacy parameter was pain...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004612/ https://www.ncbi.nlm.nih.gov/pubmed/21197285 |
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author | Grifka, Joachim Enz, Rudolf Zink, Joachim Hugot, Jean Louis Kreiss, Andreas Arulmani, Udayasankar Yu, Vincent Rebuli, Rosemary Krammer, Gerhard |
author_facet | Grifka, Joachim Enz, Rudolf Zink, Joachim Hugot, Jean Louis Kreiss, Andreas Arulmani, Udayasankar Yu, Vincent Rebuli, Rosemary Krammer, Gerhard |
author_sort | Grifka, Joachim |
collection | PubMed |
description | We compared the efficacy and safety of preemptive vs postoperative dosing of lumiracoxib 400 mg in patients undergoing minor ambulatory arthroscopic knee surgery. Eligible patients were randomized to preemptive lumiracoxib, postoperative lumiracoxib, and placebo. The main efficacy parameter was pain intensity (PI) (0–100 mm visual analog scale) in the target knee upon movement, 2 hours after surgery. Other efficacy variables included PI in the target knee at rest and upon movement at 1, 3, 4, and 24 hours, time to first rescue medication intake. In the lumiracoxib preemptive and postoperative groups, the estimated treatment difference compared to placebo for primary endpoint was −4.0 (95% CI: −9, −1; p = 0.007) and −3.5 (95% CI: −8.5, 0; p = 0.052), respectively. There was no statistical significant difference between two active treatment groups (p = 0.602). Both preemptive and postoperative lumiracoxib resulted in significantly lower PI scores at rest and after movement at all time-points and no statistically significant difference was observed between the active treatments. Time to rescue medication intake was comparable for both active treatments. The proportion of adverse events was similar among all groups. We conclude that the efficacy of lumiracoxib 400 mg is not affected by the timing of administration (preemptive or postoperative). |
format | Text |
id | pubmed-3004612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-30046122010-12-30 Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery Grifka, Joachim Enz, Rudolf Zink, Joachim Hugot, Jean Louis Kreiss, Andreas Arulmani, Udayasankar Yu, Vincent Rebuli, Rosemary Krammer, Gerhard J Pain Res Original Research We compared the efficacy and safety of preemptive vs postoperative dosing of lumiracoxib 400 mg in patients undergoing minor ambulatory arthroscopic knee surgery. Eligible patients were randomized to preemptive lumiracoxib, postoperative lumiracoxib, and placebo. The main efficacy parameter was pain intensity (PI) (0–100 mm visual analog scale) in the target knee upon movement, 2 hours after surgery. Other efficacy variables included PI in the target knee at rest and upon movement at 1, 3, 4, and 24 hours, time to first rescue medication intake. In the lumiracoxib preemptive and postoperative groups, the estimated treatment difference compared to placebo for primary endpoint was −4.0 (95% CI: −9, −1; p = 0.007) and −3.5 (95% CI: −8.5, 0; p = 0.052), respectively. There was no statistical significant difference between two active treatment groups (p = 0.602). Both preemptive and postoperative lumiracoxib resulted in significantly lower PI scores at rest and after movement at all time-points and no statistically significant difference was observed between the active treatments. Time to rescue medication intake was comparable for both active treatments. The proportion of adverse events was similar among all groups. We conclude that the efficacy of lumiracoxib 400 mg is not affected by the timing of administration (preemptive or postoperative). Dove Medical Press 2008-11-01 /pmc/articles/PMC3004612/ /pubmed/21197285 Text en © 2008 Grifka et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Grifka, Joachim Enz, Rudolf Zink, Joachim Hugot, Jean Louis Kreiss, Andreas Arulmani, Udayasankar Yu, Vincent Rebuli, Rosemary Krammer, Gerhard Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery |
title | Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery |
title_full | Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery |
title_fullStr | Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery |
title_full_unstemmed | Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery |
title_short | Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery |
title_sort | preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004612/ https://www.ncbi.nlm.nih.gov/pubmed/21197285 |
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