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Intravenous ibuprofen: the first injectable product for the treatment of pain and fever
This paper reviews the current data on the use of the first approved intravenous ibuprofen product for the management of post-operative pain and fever in the United States. The management of acute and post-operative pain and fever with nonsteroidal anti-inflammatory agents (NSAIDs) is well documente...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004645/ https://www.ncbi.nlm.nih.gov/pubmed/21197311 |
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author | Bookstaver, P Brandon Miller, April D Rudisill, Celeste N Norris, LeAnn B |
author_facet | Bookstaver, P Brandon Miller, April D Rudisill, Celeste N Norris, LeAnn B |
author_sort | Bookstaver, P Brandon |
collection | PubMed |
description | This paper reviews the current data on the use of the first approved intravenous ibuprofen product for the management of post-operative pain and fever in the United States. The management of acute and post-operative pain and fever with nonsteroidal anti-inflammatory agents (NSAIDs) is well documented. A search in Medline and International Pharmaceutical Abstracts of articles until the end of November 2009 and references of all citations were conducted. Available manufacturer data on file were also analyzed for this report. Several randomized controlled studies have demonstrated the opioid-sparing and analgesic effects of 400 and 800 mg doses of intravenous ibuprofen in a series of post-operative patient populations. Two recent studies have also noted the improvement in fever curves in critically ill and burn patients. These data, along with pharmacokinetic and pharmacologic properties, are explored in this review, which addresses the clinical utility of a parenteral NSAID in a hospitalized patient for post-operative pain management and fever reduction. Further data on intravenous ibuprofen are needed to define long-term utilization, management of acute pain, and use in special populations. |
format | Text |
id | pubmed-3004645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-30046452010-12-30 Intravenous ibuprofen: the first injectable product for the treatment of pain and fever Bookstaver, P Brandon Miller, April D Rudisill, Celeste N Norris, LeAnn B J Pain Res Review This paper reviews the current data on the use of the first approved intravenous ibuprofen product for the management of post-operative pain and fever in the United States. The management of acute and post-operative pain and fever with nonsteroidal anti-inflammatory agents (NSAIDs) is well documented. A search in Medline and International Pharmaceutical Abstracts of articles until the end of November 2009 and references of all citations were conducted. Available manufacturer data on file were also analyzed for this report. Several randomized controlled studies have demonstrated the opioid-sparing and analgesic effects of 400 and 800 mg doses of intravenous ibuprofen in a series of post-operative patient populations. Two recent studies have also noted the improvement in fever curves in critically ill and burn patients. These data, along with pharmacokinetic and pharmacologic properties, are explored in this review, which addresses the clinical utility of a parenteral NSAID in a hospitalized patient for post-operative pain management and fever reduction. Further data on intravenous ibuprofen are needed to define long-term utilization, management of acute pain, and use in special populations. Dove Medical Press 2010-05-25 /pmc/articles/PMC3004645/ /pubmed/21197311 Text en © 2010 Bookstaver et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Bookstaver, P Brandon Miller, April D Rudisill, Celeste N Norris, LeAnn B Intravenous ibuprofen: the first injectable product for the treatment of pain and fever |
title | Intravenous ibuprofen: the first injectable product for the treatment of pain and fever |
title_full | Intravenous ibuprofen: the first injectable product for the treatment of pain and fever |
title_fullStr | Intravenous ibuprofen: the first injectable product for the treatment of pain and fever |
title_full_unstemmed | Intravenous ibuprofen: the first injectable product for the treatment of pain and fever |
title_short | Intravenous ibuprofen: the first injectable product for the treatment of pain and fever |
title_sort | intravenous ibuprofen: the first injectable product for the treatment of pain and fever |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004645/ https://www.ncbi.nlm.nih.gov/pubmed/21197311 |
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